Tag | Content |
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CPLM ID | CPLM-006423 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Protein phosphatase 2C homolog 1 |
Protein Synonyms/Alias | PP2C-1 |
Gene Name | PTC1 |
Gene Synonyms/Alias | TPD1; YDL006W; D2925 |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
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188 | QAGGLIMKSRVNGML | ubiquitination | [1] |
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Reference | [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation. Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J. Nat Methods. 2013 Jul;10(7):676-82. [ PMID: 23749301] |
Functional Description | It has a serine and a weak tyrosine phosphatase activity with ratios of serine to tyrosine phosphatase activity as high as 200:1. It is essential for growth or germination at 37 degrees Celsius. May have a role in the heat shock response. Involved in tRNA splicing and cell separation. |
Sequence Annotation | METAL 58 58 Manganese 1 (By similarity). METAL 58 58 Manganese 2 (By similarity). METAL 59 59 Manganese 1; via carbonyl oxygen (By METAL 233 233 Manganese 2 (By similarity). METAL 272 272 Manganese 2 (By similarity). |
Keyword | Complete proteome; Hydrolase; Magnesium; Manganese; Metal-binding; Protein phosphatase; Reference proteome; Stress response. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 281 AA |
Protein Sequence | MSNHSEILER PETPYDITYR VGVAENKNSK FRRTMEDVHT YVKNFASRLD WGYFAVFDGH 60 AGIQASKWCG KHLHTIIEQN ILADETRDVR DVLNDSFLAI DEEINTKLVG NSGCTAAVCV 120 LRWELPDSVS DDSMDLAQHQ RKLYTANVGD SRIVLFRNGN SIRLTYDHKA SDTLEMQRVE 180 QAGGLIMKSR VNGMLAVTRS LGDKFFDSLV VGSPFTTSVE ITSEDKFLIL ACDGLWDVID 240 DQDACELIKD ITEPNEAAKV LVRYALENGT TDNVTVMVVF L 281 |
Gene Ontology | GO:0005737; C:cytoplasm; IDA:SGD. GO:0005634; C:nucleus; IDA:SGD. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0004722; F:protein serine/threonine phosphatase activity; IDA:SGD. GO:0000173; P:inactivation of MAPK activity involved in osmosensory signaling pathway; IGI:SGD. GO:0000001; P:mitochondrion inheritance; IMP:SGD. GO:0000750; P:pheromone-dependent signal transduction involved in conjugation with cellular fusion; IMP:SGD. GO:0006470; P:protein dephosphorylation; IDA:SGD. GO:0006950; P:response to stress; IEA:UniProtKB-KW. GO:0006388; P:tRNA splicing, via endonucleolytic cleavage and ligation; IMP:SGD. |
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