CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-006423
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein phosphatase 2C homolog 1 
Protein Synonyms/Alias
 PP2C-1 
Gene Name
 PTC1 
Gene Synonyms/Alias
 TPD1; YDL006W; D2925 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
188QAGGLIMKSRVNGMLubiquitination[1]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, VillĂ©n J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301
Functional Description
 It has a serine and a weak tyrosine phosphatase activity with ratios of serine to tyrosine phosphatase activity as high as 200:1. It is essential for growth or germination at 37 degrees Celsius. May have a role in the heat shock response. Involved in tRNA splicing and cell separation. 
Sequence Annotation
 METAL 58 58 Manganese 1 (By similarity).
 METAL 58 58 Manganese 2 (By similarity).
 METAL 59 59 Manganese 1; via carbonyl oxygen (By
 METAL 233 233 Manganese 2 (By similarity).
 METAL 272 272 Manganese 2 (By similarity).  
Keyword
 Complete proteome; Hydrolase; Magnesium; Manganese; Metal-binding; Protein phosphatase; Reference proteome; Stress response. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 281 AA 
Protein Sequence
MSNHSEILER PETPYDITYR VGVAENKNSK FRRTMEDVHT YVKNFASRLD WGYFAVFDGH 60
AGIQASKWCG KHLHTIIEQN ILADETRDVR DVLNDSFLAI DEEINTKLVG NSGCTAAVCV 120
LRWELPDSVS DDSMDLAQHQ RKLYTANVGD SRIVLFRNGN SIRLTYDHKA SDTLEMQRVE 180
QAGGLIMKSR VNGMLAVTRS LGDKFFDSLV VGSPFTTSVE ITSEDKFLIL ACDGLWDVID 240
DQDACELIKD ITEPNEAAKV LVRYALENGT TDNVTVMVVF L 281 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:SGD.
 GO:0005634; C:nucleus; IDA:SGD.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0004722; F:protein serine/threonine phosphatase activity; IDA:SGD.
 GO:0000173; P:inactivation of MAPK activity involved in osmosensory signaling pathway; IGI:SGD.
 GO:0000001; P:mitochondrion inheritance; IMP:SGD.
 GO:0000750; P:pheromone-dependent signal transduction involved in conjugation with cellular fusion; IMP:SGD.
 GO:0006470; P:protein dephosphorylation; IDA:SGD.
 GO:0006950; P:response to stress; IEA:UniProtKB-KW.
 GO:0006388; P:tRNA splicing, via endonucleolytic cleavage and ligation; IMP:SGD. 
Interpro
 IPR001932; PP2C-like.
 IPR000222; PP2C_Mn2_Asp60_BS.
 IPR015655; Protein_Pase_2C. 
Pfam
 PF00481; PP2C 
SMART
 SM00331; PP2C_SIG
 SM00332; PP2Cc 
PROSITE
 PS01032; PP2C 
PRINTS