| Tag | Content |
|---|
| CPLM ID | CPLM-019552 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Transmembrane protein 237 |
Protein Synonyms/Alias | Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 4 protein |
Gene Name | TMEM237 |
Gene Synonyms/Alias | ALS2CR4 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 207 | VGKVFVEKSRRFQAA | ubiquitination | [1] | | 233 | IDVSMDVKPSWTTRD | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Component of the transition zone in primary cilia. Required for ciliogenesis. |
Sequence Annotation | |
Keyword | Alternative splicing; Cell projection; Ciliopathy; Cilium; Cilium biogenesis/degradation; Complete proteome; Joubert syndrome; Membrane; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 408 AA |
Protein Sequence | MTHCACARDR AREGWGARCL GARRPPRPAK RRMGKNPVRP PRALPPVPSQ DDIPLSRPKK 60
KKPRTKNTPA SASLEGLAQT AGRRPSEGNE PSTKELKEHP EAPVQRRQKK TRLPLELETS 120
STQKKSSSSS LLRNENGIDA EPAEEAVIQK PRRKTKKTQP AELQYANELG VEDEDIITDE 180
QTTVEQQSVF TAPTGISQPV GKVFVEKSRR FQAADRSELI KTTENIDVSM DVKPSWTTRD 240
VALTVHRAFR MIGLFSHGFL AGCAVWNIVV IYVLAGDQLS NLSNLLQQYK TLAYPFQSLL 300
YLLLALSTIS AFDRIDFAKI SVAIRNFLAL DPTALASFLY FTALILSLSQ QMTSDRIHLY 360
TPSSVNGSLW EAGIEEQILQ PWIVVNLVVA LLVGLSWLFL SYRPGMDLSE ELMFSSEVEE 420
YPDKEKEIKA SS 432 |
Gene Ontology | GO:0035869; C:ciliary transition zone; IDA:UniProtKB. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0042384; P:cilium assembly; IMP:UniProtKB. GO:0030111; P:regulation of Wnt receptor signaling pathway; IMP:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |