CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-002267
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Integrin beta-1 
Protein Synonyms/Alias
 Fibronectin receptor subunit beta; Glycoprotein IIa; GPIIA; VLA-4 subunit beta; CD29 
Gene Name
 ITGB1 
Gene Synonyms/Alias
 FNRB; MDF2; MSK12 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
774EKEKMNAKWDTQENPubiquitination[1]
784TQENPIYKSPINNFKubiquitination[1]
791KSPINNFKNPNYGRKubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta- 1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha- 1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha- 3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha- 10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-4/beta-1 is a receptor for VCAM1. It recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. Isoform beta-1B interferes with isoform beta-1A resulting in a dominant negative effect on cell adhesion and migration (in vitro). In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. When associated with alpha-7/beta-1 integrin, regulates cell adhesion and laminin matrix deposition. Involved in promoting endothelial cell motility and angiogenesis. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process and the formation of mineralized bone nodules. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and GNB2L1/RACK1, serves as a platform for SRC activation or inactivation. Plays a mechanistic adhesive role during telophase, required for the successful completion of cytokinesis. 
Sequence Annotation
 DOMAIN 140 378 VWFA.
 REPEAT 466 515 I.
 REPEAT 516 559 II.
 REPEAT 560 598 III.
 REPEAT 599 635 IV.
 REGION 466 635 Cysteine-rich tandem repeats.
 REGION 785 792 Interaction with ITGB1BP1.
 METAL 152 152 Magnesium.
 METAL 154 154 Calcium 1; via carbonyl oxygen.
 METAL 156 156 Calcium 1.
 METAL 157 157 Calcium 1.
 METAL 189 189 Calcium 2.
 METAL 244 244 Calcium 2.
 METAL 246 246 Calcium 2.
 METAL 248 248 Calcium 2; via carbonyl oxygen.
 METAL 249 249 Calcium 2.
 METAL 249 249 Magnesium.
 METAL 362 362 Calcium 1; via carbonyl oxygen.
 MOD_RES 186 186 Phosphoserine (By similarity).
 MOD_RES 777 777 Phosphothreonine.
 MOD_RES 783 783 Phosphotyrosine (By similarity).
 MOD_RES 794 794 N6-acetyllysine.
 CARBOHYD 50 50 N-linked (GlcNAc...) (Potential).
 CARBOHYD 94 94 N-linked (GlcNAc...) (Potential).
 CARBOHYD 97 97 N-linked (GlcNAc...) (Potential).
 CARBOHYD 212 212 N-linked (GlcNAc...).
 CARBOHYD 269 269 N-linked (GlcNAc...).
 CARBOHYD 363 363 N-linked (GlcNAc...) (Potential).
 CARBOHYD 403 403 N-linked (GlcNAc...); atypical.
 CARBOHYD 406 406 N-linked (GlcNAc...).
 CARBOHYD 411 411 N-linked (GlcNAc...); atypical.
 CARBOHYD 417 417 N-linked (GlcNAc...) (Potential).
 CARBOHYD 481 481 N-linked (GlcNAc...).
 CARBOHYD 520 520 N-linked (GlcNAc...) (Potential).
 CARBOHYD 584 584 N-linked (GlcNAc...) (Potential).
 CARBOHYD 669 669 N-linked (GlcNAc...).
 DISULFID 27 45
 DISULFID 35 464
 DISULFID 38 64
 DISULFID 48 75
 DISULFID 207 213
 DISULFID 261 301
 DISULFID 401 415
 DISULFID 435 462
 DISULFID 466 691 Probable.
 DISULFID 477 489 By similarity.
 DISULFID 486 525 By similarity.
 DISULFID 491 500 By similarity.
 DISULFID 502 516 By similarity.
 DISULFID 531 536 By similarity.
 DISULFID 533 568 By similarity.
 DISULFID 538 553 By similarity.
 DISULFID 555 560 By similarity.
 DISULFID 574 579 By similarity.
 DISULFID 576 607 By similarity.
 DISULFID 581 590 By similarity.
 DISULFID 592 599 By similarity.
 DISULFID 613 618 By similarity.
 DISULFID 615 661 By similarity.
 DISULFID 620 630 By similarity.
 DISULFID 633 636 By similarity.
 DISULFID 640 649 By similarity.
 DISULFID 646 723 By similarity.
 DISULFID 665 699 By similarity.  
Keyword
 3D-structure; Acetylation; Alternative splicing; Calcium; Cell adhesion; Cell membrane; Cell projection; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Host cell receptor for virus entry; Host-virus interaction; Integrin; Magnesium; Membrane; Metal-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 798 AA 
Protein Sequence
MNLQPIFWIG LISSVCCVFA QTDENRCLKA NAKSCGECIQ AGPNCGWCTN STFLQEGMPT 60
SARCDDLEAL KKKGCPPDDI ENPRGSKDIK KNKNVTNRSK GTAEKLKPED ITQIQPQQLV 120
LRLRSGEPQT FTLKFKRAED YPIDLYYLMD LSYSMKDDLE NVKSLGTDLM NEMRRITSDF 180
RIGFGSFVEK TVMPYISTTP AKLRNPCTSE QNCTSPFSYK NVLSLTNKGE VFNELVGKQR 240
ISGNLDSPEG GFDAIMQVAV CGSLIGWRNV TRLLVFSTDA GFHFAGDGKL GGIVLPNDGQ 300
CHLENNMYTM SHYYDYPSIA HLVQKLSENN IQTIFAVTEE FQPVYKELKN LIPKSAVGTL 360
SANSSNVIQL IIDAYNSLSS EVILENGKLS EGVTISYKSY CKNGVNGTGE NGRKCSNISI 420
GDEVQFEISI TSNKCPKKDS DSFKIRPLGF TEEVEVILQY ICECECQSEG IPESPKCHEG 480
NGTFECGACR CNEGRVGRHC ECSTDEVNSE DMDAYCRKEN SSEICSNNGE CVCGQCVCRK 540
RDNTNEIYSG KFCECDNFNC DRSNGLICGG NGVCKCRVCE CNPNYTGSAC DCSLDTSTCE 600
ASNGQICNGR GICECGVCKC TDPKFQGQTC EMCQTCLGVC AEHKECVQCR AFNKGEKKDT 660
CTQECSYFNI TKVESRDKLP QPVQPDPVSH CKEKDVDDCW FYFTYSVNGN NEVMVHVVEN 720
PECPTGPDII PIVAGVVAGI VLIGLALLLI WKLLMIIHDR REFAKFEKEK MNAKWDTQEN 780
PIYKSPINNF KNPNYGRKAG L 801 
Gene Ontology
 GO:0001669; C:acrosomal vesicle; IEA:Compara.
 GO:0034667; C:alpha3-beta1 integrin complex; IEA:Compara.
 GO:0034678; C:alpha8-beta1 integrin complex; TAS:BHF-UCL.
 GO:0034679; C:alpha9-beta1 integrin complex; IEA:Compara.
 GO:0005604; C:basement membrane; IEA:Compara.
 GO:0009986; C:cell surface; IDA:BHF-UCL.
 GO:0032154; C:cleavage furrow; IEA:UniProtKB-SubCell.
 GO:0005737; C:cytoplasm; IDA:BHF-UCL.
 GO:0009897; C:external side of plasma membrane; IEA:Compara.
 GO:0030175; C:filopodium; IDA:BHF-UCL.
 GO:0005925; C:focal adhesion; IDA:MGI.
 GO:0030056; C:hemidesmosome; IEA:Compara.
 GO:0014704; C:intercalated disc; IEA:Compara.
 GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.
 GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.
 GO:0045121; C:membrane raft; IEA:Compara.
 GO:0035748; C:myelin sheath abaxonal region; IEA:Compara.
 GO:0031594; C:neuromuscular junction; IDA:MGI.
 GO:0001726; C:ruffle; TAS:HGNC.
 GO:0042383; C:sarcolemma; IDA:MGI.
 GO:0003779; F:actin binding; IDA:BHF-UCL.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0042277; F:peptide binding; IEA:Compara.
 GO:0046982; F:protein heterodimerization activity; NAS:UniProtKB.
 GO:0004872; F:receptor activity; IEA:InterPro.
 GO:0007411; P:axon guidance; TAS:Reactome.
 GO:0030183; P:B cell differentiation; IC:BHF-UCL.
 GO:0007596; P:blood coagulation; TAS:Reactome.
 GO:0007161; P:calcium-independent cell-matrix adhesion; IGI:MGI.
 GO:0055007; P:cardiac muscle cell differentiation; IEA:Compara.
 GO:0001708; P:cell fate specification; IEA:Compara.
 GO:0034329; P:cell junction assembly; TAS:Reactome.
 GO:0002042; P:cell migration involved in sprouting angiogenesis; IEA:Compara.
 GO:0033631; P:cell-cell adhesion mediated by integrin; IEP:BHF-UCL.
 GO:0006874; P:cellular calcium ion homeostasis; IEA:Compara.
 GO:0006968; P:cellular defense response; TAS:ProtInc.
 GO:0071479; P:cellular response to ionizing radiation; IEA:Compara.
 GO:0071260; P:cellular response to mechanical stimulus; IEA:Compara.
 GO:0071305; P:cellular response to vitamin D; IEA:Compara.
 GO:0030198; P:extracellular matrix organization; TAS:Reactome.
 GO:0000082; P:G1/S transition of mitotic cell cycle; IEA:Compara.
 GO:0008354; P:germ cell migration; IEA:Compara.
 GO:0007156; P:homophilic cell adhesion; TAS:ProtInc.
 GO:0001701; P:in utero embryonic development; IEA:Compara.
 GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
 GO:0007159; P:leukocyte cell-cell adhesion; IDA:BHF-UCL.
 GO:0050900; P:leukocyte migration; TAS:Reactome.
 GO:0060135; P:maternal process involved in female pregnancy; IEA:Compara.
 GO:2000811; P:negative regulation of anoikis; IMP:UniProtKB.
 GO:0031345; P:negative regulation of cell projection organization; IEA:Compara.
 GO:0008285; P:negative regulation of cell proliferation; IEA:Compara.
 GO:0045665; P:negative regulation of neuron differentiation; IEA:Compara.
 GO:0043065; P:positive regulation of apoptotic process; IGI:MGI.
 GO:0030335; P:positive regulation of cell migration; IEA:Compara.
 GO:0008284; P:positive regulation of cell proliferation; IEA:Compara.
 GO:0010811; P:positive regulation of cell-substrate adhesion; IEA:Compara.
 GO:0045807; P:positive regulation of endocytosis; IEA:Compara.
 GO:0043410; P:positive regulation of MAPK cascade; IEA:Compara.
 GO:0045666; P:positive regulation of neuron differentiation; IEA:Compara.
 GO:0010976; P:positive regulation of neuron projection development; IEA:Compara.
 GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IEA:Compara.
 GO:0032594; P:protein transport within lipid bilayer; IEA:Compara.
 GO:0051726; P:regulation of cell cycle; IEA:Compara.
 GO:0008277; P:regulation of G-protein coupled receptor protein signaling pathway; IEA:Compara.
 GO:0050776; P:regulation of immune response; TAS:Reactome.
 GO:0014823; P:response to activity; IEA:Compara.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0034698; P:response to gonadotropin stimulus; IEA:Compara.
 GO:0071559; P:response to transforming growth factor beta stimulus; IEA:Compara.
 GO:0045214; P:sarcomere organization; IEA:Compara.
 GO:0070830; P:tight junction assembly; IEA:Compara.
 GO:0001894; P:tissue homeostasis; IEA:Compara.
 GO:0019048; P:virus-host interaction; IEA:UniProtKB-KW. 
Interpro
 IPR013111; EGF_extracell.
 IPR027071; Integrin_beta-1.
 IPR015812; Integrin_bsu.
 IPR014836; Integrin_bsu_cyt_dom.
 IPR002369; Integrin_bsu_N.
 IPR012896; Integrin_bsu_tail.
 IPR003659; Plexin-like.
 IPR016201; Plexin-like_fold.
 IPR002035; VWF_A. 
Pfam
 PF07974; EGF_2
 PF08725; Integrin_b_cyt
 PF07965; Integrin_B_tail
 PF00362; Integrin_beta 
SMART
 SM00187; INB
 SM00423; PSI
 SM00327; VWA 
PROSITE
 PS00022; EGF_1
 PS00243; INTEGRIN_BETA
 PS50234; VWFA 
PRINTS
 PR01186; INTEGRINB.