UniProt Accession

 RL13A_MOUSE; P19253 

Genbank Protein ID

 X51528; BC082289 

Genbank Nucleotide ID

 CAA35908.1; AAH82289.1 

Protein Name

 60S ribosomal protein L13a 

Protein Synonyms/Alias

 Transplantation antigen P198; Tum-P198 antigen 

Gene Name

 Rpl13a 

Gene Synonyms/Alias

 P198; Tstap198-7 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
183	RLRKQAEKNVEKKIC	acetylation	[1]
188	AEKNVEKKICKFTEV	acetylation	[1]
191	NVEKKICKFTEVLKT	acetylation	[1]

Reference

 [1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123] 

Functional Description

 Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions (By similarity). Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma- induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop- containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. In the GAIT complex interacts with m7G cap-bound eIF4G at or near the eIF3-binding site and blocks the recruitment of the 43S ribosomal complex. 

Sequence Annotation

 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 77 77 Phosphoserine; by ZIPK/DAPK3.
 MOD_RES 191 191 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Complete proteome; Direct protein sequencing; Phosphoprotein; Polymorphism; Reference proteome; Ribonucleoprotein; Ribosomal protein; Translation regulation; Tumor antigen. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 203 AA 

Protein Sequence

Gene Ontology

 GO:0015934; C:large ribosomal subunit; IEA:InterPro.
 GO:0030529; C:ribonucleoprotein complex; ISO:MGI.
 GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
 GO:0071346; P:cellular response to interferon-gamma; IDA:UniProtKB.
 GO:0017148; P:negative regulation of translation; IDA:UniProtKB.
 GO:0006412; P:translation; IEA:InterPro. 

Interpro

 IPR005822; Ribosomal_L13.
 IPR023563; Ribosomal_L13_CS.
 IPR023564; Ribosomal_L13_dom.
 IPR005755; Ribosomal_L13_euk/arc. 

Pfam

 PF00572; Ribosomal_L13 

SMART

  

PROSITE

 PS00783; RIBOSOMAL_L13 

PRINTS