CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-042060
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Negative elongation factor C/D 
Protein Synonyms/Alias
 TH1-like (Drosophila), isoform CRA_b 
Gene Name
 TH1L 
Gene Synonyms/Alias
 NELFCD; hCG_28547 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
76PSIFNTLKRYFQAGGubiquitination[1, 2, 3, 4, 5, 6]
134HLKSLLIKHFDPRKAubiquitination[1, 5]
231GGEENLEKNLPEFAKubiquitination[3]
281VQRFAQEKGHDASQIubiquitination[5]
311ALGAMLSKGALNPADubiquitination[3]
389NKRVSINKDELKSTSubiquitination[5]
393SINKDELKSTSKAVEubiquitination[3]
397DELKSTSKAVETVHNubiquitination[3]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [4] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [5] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [6] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 599 AA 
Protein Sequence
MRRARSREGM AGAVPGAIMD EDYYGSAAEW GDEADGGQQE DDSGEGEDDA EVQQECLHKF 60
STRDYIMEPS IFNTLKRYFQ AGGSPENVIQ LLSENYTAVA QTVNLLAEWL IQTGVEPVQV 120
QETVENHLKS LLIKHFDPRK ADSIFTEEGE TPAWLEQMIA HTTWRDLFYK LAEAHPDCLM 180
LNFTVKLISD AGYQGEITSV STACQQLEVF SRVLRTSLAT ILDGGEENLE KNLPEFAKMV 240
CHGEHTYLFA QAMMSVLAQE EQGGSAVRRI AQEVQRFAQE KGHDASQITL ALGTAASYPR 300
ACQALGAMLS KGALNPADIT VLFKMFTSMD PPPVELIRVP AFLDLFMQSL FKPGARINQD 360
HKHKYIHILA YAASVVETWK KNKRVSINKD ELKSTSKAVE TVHNLCCNEN KGASELVAEL 420
STLYQCIRFP VVAMGVLKWV DWTVSEPRYF QLQTDHTPVH LALLDEISTC HQLLHPQVLQ 480
LLVKLFETEH SQLDVMEQLE LKKTLLDRMV HLLSRGYVLP VVSYIRKCLE KLDTDISLIR 540
YFVTEVLDVI APPYTSDFVQ LFLPILENDS IAGTIKTEGE HDPVTEFIAH CKSNFIMVN 599 
Gene Ontology
 GO:0005634; C:nucleus; IEA:InterPro.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IEA:InterPro. 
Interpro
 IPR006942; TH1. 
Pfam
 PF04858; TH1 
SMART
  
PROSITE
  
PRINTS