CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038023
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Protein Slc12a2 
Protein Synonyms/Alias
  
Gene Name
 Slc12a2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
271VTYTAESKGVVKFGWubiquitination[1]
832EMSIDQAKYQRWLIKacetylation[2]
934ELLSSQEKSPGTKDVubiquitination[1]
939QEKSPGTKDVVVNVDubiquitination[1]
986PLLKKESKGPVAPLNubiquitination[1]
1069AMATLLSKFRIDFSDacetylation[2]
1089DINTKPKKENIVAFDubiquitination[1]
1134DNELELYKTKTYRQIacetylation[2]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113]
 [2] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1203 AA 
Protein Sequence
MEPGPAAPSS GAPRPARDGD APLTAAGVDL PGTAVLSGRE DATAGSQAGG GVRGEGTPAA 60
GDGLGKPLGP TPSQSRFQVD PVSENAGRAA AAAAAAAAAA AAGAAGKETP AAGKAGTESG 120
VAKGSEEAKG RFRVNFVDPA ASSSADDSLS DAAGVGGDGP NVSFQNGGDT VLSEGSSLHS 180
GGGSGHHQQY YYDTHTNTYY LRTFGHNTMD AVPRIDHYRH TAAQLGEKLL RPSLAELHDE 240
LEKEPFEDGF ANGEESTPTR DAVVTYTAES KGVVKFGWIK GVLVRCMLNI WGVMLFIRLS 300
WIVGQAGIGL SVLVIAMATV VTTITGLSTS AIATNGFVRG GGAYYLISRS LGPEFGGAIG 360
LIFAFANAVA VAMYVVGFAE TVVELLKEHS ILMIDEINDI RIIGAITVVV LLGISVAGME 420
WEAKAQIVLL VILLLAIADF VIGTFISLDS KKPKGFFGYK SEIFSENFGP DFREEETFFS 480
VFAIFFPAAT GILAGANISG DLADPQSAIP KGTLLAILIT TVVYIGIAVS VGSCVVRDAT 540
GNVNDTITTE LTNCTSAACK LNFDFSYCES NTCSYGLMNN FQVMSMVSGF APLISAGIFS 600
ATLSSALASL VSAPKIFQAL CKDNIYPAFQ MFAKGYGKNN EPLRGYILTF LIALGFILIA 660
ELNVIAPIIS NFFLASYALI NFSVFHASLA KSPGWRPAFK YYNMWISLTG AILCCIVMFV 720
INWWAALLTY VIVLGLYIYV TYKKPDVNWG SSTQALTYLS ALQHSIRLSG VEDHVKNFRP 780
QCLVMTGSPN SRPALLHLVH DFTKNVGLMI CGHVHMGPRR QAMKEMSIDQ AKYQRWLIKN 840
KMKAFYAPVH ADDLREGAQY LMQAAGLGRM KPNTLVLGFK KDWLQADMRD VDMYINLFHD 900
AFDIQYGVVV IRLKEGLDIS HLQGQEELLS SQEKSPGTKD VVVNVDYSKK SDQDAFKASG 960
EKPITQKDEE EDGKTSTQPL LKKESKGPVA PLNVADQKLL EASTQFQKKQ GKNTIDVWWL 1020
FDDGGLTLLI PYLLTTKKKW KDCKIRVFIG GKINRIDHDR RAMATLLSKF RIDFSDIMVL 1080
GDINTKPKKE NIVAFDDMIE PYRLHEDDKE QDIADKMKED EPWRITDNEL ELYKTKTYRQ 1140
IRLNELLKEH SSTANIIVMS LPVARKGAVS SALYMAWLEA LSKDLPPILL VRGNHQSVLT 1200
FYS 1203 
Gene Ontology
 GO:0016324; C:apical plasma membrane; IEA:Compara.
 GO:0016323; C:basolateral plasma membrane; IEA:Compara.
 GO:0016021; C:integral to membrane; IEA:InterPro.
 GO:0005886; C:plasma membrane; IDA:RGD.
 GO:0051739; F:ammonia transmembrane transporter activity; IEA:Compara.
 GO:0008511; F:sodium:potassium:chloride symporter activity; IMP:RGD.
 GO:0060444; P:branching involved in mammary gland duct morphogenesis; IEA:Compara.
 GO:0050910; P:detection of mechanical stimulus involved in sensory perception of sound; IEA:Compara.
 GO:0007214; P:gamma-aminobutyric acid signaling pathway; IEP:RGD.
 GO:0006972; P:hyperosmotic response; IMP:RGD.
 GO:0060763; P:mammary duct terminal end bud growth; IEA:Compara.
 GO:0035264; P:multicellular organism growth; IEA:Compara.
 GO:0045795; P:positive regulation of cell volume; IMP:RGD.
 GO:0006813; P:potassium ion transport; IMP:RGD.
 GO:0006814; P:sodium ion transport; IMP:RGD.
 GO:0070634; P:transepithelial ammonium transport; IEA:Compara.
 GO:0030321; P:transepithelial chloride transport; IEA:Compara. 
Interpro
 IPR004841; AA-permease_dom.
 IPR013612; AA_permease_N.
 IPR002443; Na/K/Cl_cotranspt.
 IPR002444; Na/K/Cl_cotranspt1.
 IPR004842; Na/K/Cl_cotransptS. 
Pfam
 PF00324; AA_permease
 PF08403; AA_permease_N 
SMART
  
PROSITE
  
PRINTS
 PR01207; NAKCLTRNSPRT.
 PR01208; NAKCLTRSPRT1.