CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000550
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Neural cell adhesion molecule 2 
Protein Synonyms/Alias
 N-CAM-2; NCAM-2; Neural cell adhesion molecule RB-8; R4B12 
Gene Name
 Ncam2 
Gene Synonyms/Alias
 Ocam; Rncam 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
757SKELEEGKAAYLKDGubiquitination[1]
831SNDIIQSKEDDIKA*ubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 May play important roles in selective fasciculation and zone-to-zone projection of the primary olfactory axons. 
Sequence Annotation
 DOMAIN 21 108 Ig-like C2-type 1.
 DOMAIN 113 202 Ig-like C2-type 2.
 DOMAIN 208 297 Ig-like C2-type 3.
 DOMAIN 302 396 Ig-like C2-type 4.
 DOMAIN 401 491 Ig-like C2-type 5.
 DOMAIN 496 588 Fibronectin type-III 1.
 DOMAIN 590 684 Fibronectin type-III 2.
 MOD_RES 780 780 Phosphothreonine.
 CARBOHYD 177 177 N-linked (GlcNAc...) (Potential).
 CARBOHYD 219 219 N-linked (GlcNAc...) (Potential).
 CARBOHYD 309 309 N-linked (GlcNAc...) (Potential).
 CARBOHYD 406 406 N-linked (GlcNAc...) (Potential).
 CARBOHYD 419 419 N-linked (GlcNAc...) (Potential).
 CARBOHYD 445 445 N-linked (GlcNAc...) (Potential).
 CARBOHYD 474 474 N-linked (GlcNAc...) (Potential).
 CARBOHYD 562 562 N-linked (GlcNAc...) (Potential).
 DISULFID 42 93 Probable.
 DISULFID 136 186 Probable.
 DISULFID 232 281 Probable.
 DISULFID 322 380 Probable.
 DISULFID 422 475 Probable.  
Keyword
 Alternative splicing; Cell adhesion; Cell membrane; Complete proteome; Disulfide bond; Glycoprotein; GPI-anchor; Immunoglobulin domain; Lipoprotein; Membrane; Phosphoprotein; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 837 AA 
Protein Sequence
MSLLLSFYLL GLLVRSGQAL LQVTISLSKV ELSVGESKFF TCTAIGEPES IDWYNPQGEK 60
IISTQRVMLQ KEGVRSRLTI YNANIEDAGI YRCQATDAKG QTQEATVVLE IYQKLTFREV 120
VSPQEFKQGE DAEVVCRVSS SPAPAVSWLY HNEEVTTIPD NRFAVLANNN LQILNINKSD 180
EGIYRCEGRV EARGEIDFRD IIVIVNVPPA IMMPQKSFNA TAERGEEMTL TCKASGSPDP 240
TISWFRNGKL IEENEKYILK GSNTELTVRN IINKDGGSYV CKATNKAGED QKQAFLQVFV 300
QPHILQLKNE TTSENGHVTL VCEAEGEPVP EITWKRAIDG VMFSEGDKSP DGRIEVKGQH 360
GRSSLHIRDV KLSDSGRYDC EAASRIGGHQ RSMHLDIEYA PKFVSNQTMY YSWEGNPINI 420
SCDVTANPPA SIHWRREKLL LPAKNTTHLK THSVGRKMIL EIAPTSDNDF GRYNCTATNR 480
IGTRFQEYIL ELADVPSSPH GVKIIELSQT TAKISFNKPE SHGGVPIHHY QVDVKEVASE 540
TWKIVRSHGV QTMVVLSSLE PNTTYEIRVA AVNGKGQGDY SKIEIFQTLP VREPSPPSIH 600
GQPSSGKSFK ISITKQDDGG APILEYIVKY RSKDKEDQWL EKKVQGNKDH IILEHLQWTM 660
GYEVQITAAN RLGYSEPTVY EFSMPPKPNI IKDTLFNGLG LGAIIGLGVA ALLLILVVTD 720
VSCFFIRQCG LLMCITRRMC GKKSGSSGKS KELEEGKAAY LKDGSKEPIV EMRTEDERIT 780
NHEDGSPVNE PNETTPLTEP EKLPLKEENG KEVLNAETIE IKVSNDIIQS KEDDIKA 837 
Gene Ontology
 GO:0031225; C:anchored to membrane; IEA:UniProtKB-KW.
 GO:0030424; C:axon; IDA:MGI.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0007155; P:cell adhesion; IEA:UniProtKB-KW. 
Interpro
 IPR003961; Fibronectin_type3.
 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR013098; Ig_I-set.
 IPR003598; Ig_sub2.
 IPR009138; Neural_cell_adh. 
Pfam
 PF00041; fn3
 PF07679; I-set 
SMART
 SM00060; FN3
 SM00408; IGc2 
PROSITE
 PS50853; FN3
 PS50835; IG_LIKE 
PRINTS
 PR01838; NCAMFAMILY.