UniProt Accession

 GRPE_MYCPN; P78017 

Genbank Protein ID

 U00089 

Genbank Nucleotide ID

 AAB95682.1 

Protein Name

 Protein GrpE 

Protein Synonyms/Alias

 HSP-70 cofactor 

Gene Name

 grpE 

Gene Synonyms/Alias

 MPN_120; MP034 

Created Date

 July 27, 2013 

Organism

 Mycoplasma pneumoniae (strain ATCC 29342 / M129) 

NCBI Taxa ID

 272634 

Lysine Modification

Position	Peptide	Type	References
21	SIRTLLVKHNKAKVT	acetylation	[1]
32	AKVTQIEKELLQAVA	acetylation	[1]
43	QAVAELEKKFKQQVQ	acetylation	[1]
64	QKIPNLQKVNEEFRL	acetylation	[1]
96	AELTIKSKEELENAK	acetylation	[1]
197	KVSKSGYKLHDKVIR	acetylation	[1]

Reference

 [1] Cross-talk between phosphorylation and lysine acetylation in a genome-reduced bacterium.
 van Noort V, Seebacher J, Bader S, Mohammed S, Vonkova I, Betts MJ, Kühner S, Kumar R, Maier T, O'Flaherty M, Rybin V, Schmeisky A, Yus E, Stülke J, Serrano L, Russell RB, Heck AJ, Bork P, Gavin AC.
 Mol Syst Biol. 2012 Feb 28;8:571. [PMID: 22373819] 

Functional Description

 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding (By similarity). 

Sequence Annotation

  

Keyword

 Chaperone; Complete proteome; Cytoplasm; Reference proteome; Stress response. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 217 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0000774; F:adenyl-nucleotide exchange factor activity; IEA:InterPro.
 GO:0006457; P:protein folding; IEA:InterPro.
 GO:0006950; P:response to stress; IEA:UniProtKB-KW. 

Interpro

 IPR000740; GrpE.
 IPR013805; GrpE_coiled_coil.
 IPR009012; GrpE_head. 

Pfam

 PF01025; GrpE 

SMART

  

PROSITE

 PS01071; GRPE 

PRINTS

 PR00773; GRPEPROTEIN.