CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024095
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 V-type proton ATPase subunit C 1 
Protein Synonyms/Alias
 V-ATPase subunit C 1; Vacuolar proton pump subunit C 1 
Gene Name
 Atp6v1c1 
Gene Synonyms/Alias
 Atp6c; Atp6c1; Vatc 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
28KLHAATTKNNNLAVSubiquitination[1]
86VLEDSKDKVQENLLAubiquitination[1]
115DMAKYPIKQSLKNISubiquitination[1]
127NISEIIAKGVTQIDNubiquitination[1]
137TQIDNDLKSRASAYNubiquitination[1]
147ASAYNNLKGNLQNLEubiquitination[1]
156NLQNLERKNAGSLLTubiquitination[1]
240AVDDFRHKARENKFIubiquitination[1]
259QYNEEEMKADKEEMTubiquitination[1]
262EEEMKADKEEMTRLSubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. 
Sequence Annotation
 MOD_RES 2 2 N-acetylthreonine (By similarity).  
Keyword
 Acetylation; Complete proteome; Direct protein sequencing; Hydrogen ion transport; Ion transport; Reference proteome; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 382 AA 
Protein Sequence
MTEFWLISAP GEKTCQQTWE KLHAATTKNN NLAVSSKFNI PDLKVGTLDV LVGLSDELAK 60
LDAFVEGVVK KVAQYMADVL EDSKDKVQEN LLASGVDLVT YITRFQWDMA KYPIKQSLKN 120
ISEIIAKGVT QIDNDLKSRA SAYNNLKGNL QNLERKNAGS LLTRSLAEIV KKDDFVLDSE 180
YLVTLLVVVP KLNHNDWIKQ YETLAEMVVP RSSNVLSEDQ DSYLCNVTLF RKAVDDFRHK 240
ARENKFIVRD FQYNEEEMKA DKEEMTRLST DKKKQFGPLV RWLKVNFSEA FIAWIHIKAL 300
RVFVESVLRY GLPVNFQAML LQPNKKSVKK LREVLHELYK HLDSSAAAII DAPMDIPGLN 360
LSQQEYYPYV YYKIDCNLLE FK 382 
Gene Ontology
 GO:0045177; C:apical part of cell; IEA:Compara.
 GO:0031410; C:cytoplasmic vesicle; IEA:Compara.
 GO:0005886; C:plasma membrane; IDA:UniProtKB.
 GO:0033180; C:proton-transporting V-type ATPase, V1 domain; IEA:InterPro.
 GO:0008553; F:hydrogen-exporting ATPase activity, phosphorylative mechanism; IDA:MGI.
 GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro. 
Interpro
 IPR004907; ATPase_V1-cplx_csu. 
Pfam
 PF03223; V-ATPase_C 
SMART
  
PROSITE
  
PRINTS