CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004180
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Ras-related protein RSR1 
Protein Synonyms/Alias
  
Gene Name
 RSR1 
Gene Synonyms/Alias
 BUD1; YGR152C; G6658 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
176EMESVAVKDARNQSQubiquitination[1]
187NQSQQFSKIESPSTRubiquitination[1]
200TRLPSSAKQDTKQSNubiquitination[1]
218SSKGLYNKSSQGQAKubiquitination[1]
237TPVNEKHKPSHAVPKubiquitination[2]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, VillĂ©n J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [2] Sites of ubiquitin attachment in Saccharomyces cerevisiae.
 Starita LM, Lo RS, Eng JK, von Haller PD, Fields S.
 Proteomics. 2012 Jan;12(2):236-40. [PMID: 22106047
Functional Description
 Involved in development of cell polarity during the cell division cycle, and essential for bud emergence. RSR1 and CDC24 interact functionally and perhaps physically. 
Sequence Annotation
 NP_BIND 10 17 GTP (By similarity).
 NP_BIND 57 61 GTP (By similarity).
 NP_BIND 116 119 GTP (By similarity).
 MOTIF 32 40 Effector region (Potential).
 MOD_RES 269 269 Cysteine methyl ester (By similarity).
 LIPID 269 269 S-geranylgeranyl cysteine (By  
Keyword
 Cell cycle; Cell division; Cell membrane; Complete proteome; GTP-binding; Lipoprotein; Membrane; Methylation; Nucleotide-binding; Prenylation; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 272 AA 
Protein Sequence
MRDYKLVVLG AGGVGKSCLT VQFVQGVYLD TYDPTIEDSY RKTIEIDNKV FDLEILDTAG 60
IAQFTAMREL YIKSGMGFLL VYSVTDRQSL EELMELREQV LRIKDSDRVP MVLIGNKADL 120
INERVISVEE GIEVSSKWGR VPFYETSALL RSNVDEVFVD LVRQIIRNEM ESVAVKDARN 180
QSQQFSKIES PSTRLPSSAK QDTKQSNNKQ SSKGLYNKSS QGQAKVKQST PVNEKHKPSH 240
AVPKSGSSNR TGISATSQQK KKKKNASTCT IL 272 
Gene Ontology
 GO:0005935; C:cellular bud neck; IDA:SGD.
 GO:0005886; C:plasma membrane; IDA:SGD.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0003924; F:GTPase activity; IDA:SGD.
 GO:0004871; F:signal transducer activity; TAS:SGD.
 GO:0007120; P:axial cellular bud site selection; TAS:SGD.
 GO:0007121; P:bipolar cellular bud site selection; TAS:SGD.
 GO:0007264; P:small GTPase mediated signal transduction; TAS:SGD. 
Interpro
 IPR027417; P-loop_NTPase.
 IPR005225; Small_GTP-bd_dom.
 IPR001806; Small_GTPase.
 IPR020849; Small_GTPase_Ras. 
Pfam
 PF00071; Ras 
SMART
 SM00173; RAS 
PROSITE
 PS51421; RAS 
PRINTS
 PR00449; RASTRNSFRMNG.