CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024156
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Nexilin 
Protein Synonyms/Alias
  
Gene Name
 Nexn 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
34GKGDVKDKFEAMQRAacetylation[1]
104LTGTVKGKFDEMEKHacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Involved in regulating cell migration through association with the actin cytoskeleton (By similarity). Has an essential role in the maintenance of Z line and sarcomere integrity (By similarity). 
Sequence Annotation
 DOMAIN 562 650 Ig-like.
 MOD_RES 80 80 Phosphoserine (By similarity).
 MOD_RES 221 221 Phosphoserine (By similarity).
 MOD_RES 337 337 Phosphoserine (By similarity).
 MOD_RES 345 345 Phosphoserine (By similarity).
 MOD_RES 350 350 Phosphothreonine (By similarity).  
Keyword
 Actin-binding; Alternative splicing; Cell junction; Complete proteome; Cytoplasm; Cytoskeleton; Immunoglobulin domain; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 656 AA 
Protein Sequence
MNDVSQKAEI LLSSSKPVPK SYVPKLGKGD VKDKFEAMQR AREERNQRRS RDEKQRRKEQ 60
YIREREWNRR KQEIKDMLAS DEEEEPSKVE KAYVPKLTGT VKGKFDEMEK HRQEEQRKRT 120
EEERKRRIEQ DLLEKRKMQR ELAKRAEQEG DDSLLITVVP AKSYRAAANR KDPEDLDREH 180
RNGRVSQEEE KTRHEEECRA LKEAKCLSLV MDDETEAKKE SRFPGKLKST FEELERQRQE 240
NRKKQAEEEA RRRLEEERRA FEEARRNMVN EEDESQDTET VFKEYRPGKL RLSFEEIERQ 300
RREEEKRKAE EEARRRMEEE KKAFAEARRS MVLDDDSPEI YKAVSQESLT PGKLEINFEQ 360
LLRQKMEEER RRTEEERRQK LEMEKQEFEQ LRQEMGKEEE ENESFGLSRE YEELIKLKRS 420
GSIQAKNLKS KFEKIGQLSE KEVQKKIEEE RAKRRAIDLE IKEREAENFH EDDDVDVKPA 480
KKSESPFTHK VNMKARFEQM AKARQEEEQR RIEEQKLLRM QFEQKEIDAA LQKKREDDEE 540
EEGSIVNGST TEDEEQTRSG APWFKKPLRN TSVVDSEPVR FTVKVTGEPK PEVTWWFEGE 600
LLQDGEDYQY IERGETYCLY LPETFPEDGG EYMCKAVNSK GSAASTCILT IEMDDY 656 
Gene Ontology
 GO:0005924; C:cell-substrate adherens junction; IDA:UniProtKB.
 GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
 GO:0030018; C:Z disc; IDA:UniProtKB.
 GO:0051015; F:actin filament binding; IDA:RGD.
 GO:0008307; F:structural constituent of muscle; ISS:UniProtKB.
 GO:0030334; P:regulation of cell migration; ISS:UniProtKB.
 GO:0051493; P:regulation of cytoskeleton organization; ISS:UniProtKB. 
Interpro
 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR013098; Ig_I-set.
 IPR003599; Ig_sub.
 IPR020675; Myosin_light_ch_kinase-rel.
 IPR020678; Nexilin. 
Pfam
 PF07679; I-set 
SMART
 SM00409; IG 
PROSITE
 PS50835; IG_LIKE 
PRINTS