UniProt Accession

 GDIR1_RAT; Q5XI73 

Genbank Protein ID

 BC083817 

Genbank Nucleotide ID

 AAH83817.1 

Protein Name

 Rho GDP-dissociation inhibitor 1 

Protein Synonyms/Alias

 Rho GDI 1; Rho-GDI alpha 

Gene Name

 Arhgdia 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
28	DEHSVNYKPPAQKSI	acetylation	[1]
43	QEIQELDKDDESLRK	acetylation	[1]
52	DESLRKYKEALLGRV	acetylation	[1]
99	GDLESFKKQSFVLKE	acetylation	[1]
105	KKQSFVLKEGVEYRI	acetylation	[1]
113	EGVEYRIKISFRVNR	acetylation	[1]
127	REIVSGMKYIQHTYR	acetylation	[1]
138	HTYRKGVKIDKTDYM	acetylation	[1]
141	RKGVKIDKTDYMVGS	acetylation	[1]
141	RKGVKIDKTDYMVGS	ubiquitination	[2]
167	TPMEEAPKGMLARGS	acetylation	[1]
178	ARGSYNIKSRFTDDD	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 

Functional Description

 Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them (By similarity). In glioma cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1. 

Sequence Annotation

 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 105 105 N6-acetyllysine (By similarity).
 MOD_RES 127 127 N6-acetyllysine (By similarity).
 MOD_RES 141 141 N6-acetyllysine (By similarity).
 MOD_RES 178 178 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Complete proteome; Cytoplasm; GTPase activation; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 204 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0001772; C:immunological synapse; IEA:Compara.
 GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
 GO:0005094; F:Rho GDP-dissociation inhibitor activity; IEA:Compara.
 GO:0043547; P:positive regulation of GTPase activity; IEA:GOC.
 GO:0032880; P:regulation of protein localization; IEA:Compara.
 GO:0007266; P:Rho protein signal transduction; IEA:Compara. 

Interpro

 IPR014756; Ig_E-set.
 IPR000406; Rho_GDI.
 IPR024792; RhoGDI_domain. 

Pfam

 PF02115; Rho_GDI 

SMART

  

PROSITE

  

PRINTS

 PR00492; RHOGDI.