UniProt Accession

 SIX6_HUMAN; O95475; Q6NT42; Q9P1X8 

Genbank Protein ID

 AF031648; AJ011785; AF141651; BC069413; AB041399 

Genbank Nucleotide ID

 AAF04402.1; CAA09773.1; AAD49844.1; AAH69413.2; BAA94484.1 

Protein Name

 Homeobox protein SIX6 

Protein Synonyms/Alias

 Homeodomain protein OPTX2; Optic homeobox 2; Sine oculis homeobox homolog 6 

Gene Name

 SIX6 

Gene Synonyms/Alias

 OPTX2; SIX9 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
49	AACEALNKNESVLRA	ubiquitination	[1, 2, 3]
78	YHILENHKFTKESHA	ubiquitination	[3]
101	AHYQEAEKLRGRPLG	ubiquitination	[2]
131	TIWDGEQKTHCFKER	ubiquitination	[2]

Reference

 [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 May be involved in eye development. 

Sequence Annotation

 DNA_BIND 128 187 Homeobox.
 MOD_RES 212 212 Phosphothreonine.
 MOD_RES 221 221 Phosphoserine.
 MOD_RES 225 225 Phosphoserine.
 MOD_RES 227 227 Phosphoserine.
 MOD_RES 228 228 Phosphoserine.  

Keyword

 Cataract; Complete proteome; Developmental protein; Disease mutation; DNA-binding; Homeobox; Microphthalmia; Nucleus; Phosphoprotein; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 246 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
 GO:0009887; P:organ morphogenesis; TAS:ProtInc.
 GO:0007601; P:visual perception; TAS:ProtInc. 

Interpro

 IPR001356; Homeodomain.
 IPR009057; Homeodomain-like. 

Pfam

 PF00046; Homeobox 

SMART

 SM00389; HOX 

PROSITE

 PS00027; HOMEOBOX_1
 PS50071; HOMEOBOX_2 

PRINTS