| Tag | Content |
|---|
| CPLM ID | CPLM-023807 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Zinc finger protein 175 |
Protein Synonyms/Alias | Zinc finger protein OTK18 |
Gene Name | ZNF175 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 594 | YVCTECGKAFNGRSN | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Down-regulates the expression of several chemokine receptors. Interferes with HIV-1 replication by suppressing Tat- induced viral LTR promoter activity. |
Sequence Annotation | DOMAIN 27 98 KRAB.
ZN_FING 279 301 C2H2-type 1; atypical.
ZN_FING 307 329 C2H2-type 2; atypical.
ZN_FING 335 357 C2H2-type 3.
ZN_FING 363 385 C2H2-type 4.
ZN_FING 391 413 C2H2-type 5.
ZN_FING 419 441 C2H2-type 6.
ZN_FING 447 469 C2H2-type 7.
ZN_FING 475 497 C2H2-type 8.
ZN_FING 503 525 C2H2-type 9.
ZN_FING 531 553 C2H2-type 10.
ZN_FING 559 581 C2H2-type 11.
ZN_FING 587 609 C2H2-type 12.
ZN_FING 615 637 C2H2-type 13.
ZN_FING 643 665 C2H2-type 14.
ZN_FING 671 693 C2H2-type 15.
MOTIF 359 362 Nuclear localization signal (Potential). |
Keyword | Antiviral defense; Complete proteome; Cytoplasm; DNA-binding; Metal-binding; Nucleus; Polymorphism; Reference proteome; Repeat; Repressor; Transcription; Transcription regulation; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 711 AA |
Protein Sequence | MPADVNLSQK PQVLGPEKQD GSCEASVSFE DVTVDFSREE WQQLDPAQRC LYRDVMLELY 60
SHLFAVGYHI PNPEVIFRML KEKEPRVEEA EVSHQRCQER EFGLEIPQKE ISKKASFQKD 120
MVGEFTRDGS WCSILEELRL DADRTKKDEQ NQIQPMSHSA FFNKKTLNTE SNCEYKDPGK 180
MIRTRPHLAS SQKQPQKCCL FTESLKLNLE VNGQNESNDT EQLDDVVGSG QLFSHSSSDA 240
CSKNIHTGET FCKGNQCRKV CGHKQSLKQH QIHTQKKPDG CSECGGSFTQ KSHLFAQQRI 300
HSVGNLHECG KCGKAFMPQL KLSVYLTDHT GDIPCICKEC GKVFIQRSEL LTHQKTHTRK 360
KPYKCHDCGK AFFQMLSLFR HQRTHSREKL YECSECGKGF SQNSTLIIHQ KIHTGERQYA 420
CSECGKAFTQ KSTLSLHQRI HSGQKSYVCI ECGQAFIQKA HLIVHQRSHT GEKPYQCHNC 480
GKSFISKSQL DIHHRIHTGE KPYECSDCGK TFTQKSHLNI HQKIHTGERH HVCSECGKAF 540
NQKSILSMHQ RIHTGEKPYK CSECGKAFTS KSQFKEHQRI HTGEKPYVCT ECGKAFNGRS 600
NFHKHQITHT RERPFVCYKC GKAFVQKSEL ITHQRTHMGE KPYECLDCGK SFSKKPQLKV 660
HQRIHTGERP YVCSECGKAF NNRSNFNKHQ TTHTRDKSYK CSYSVKGFTK Q 711 |
Gene Ontology | GO:0005737; C:cytoplasm; IDA:HPA. GO:0045111; C:intermediate filament cytoskeleton; IDA:HPA. GO:0005634; C:nucleus; IDA:HPA. GO:0003677; F:DNA binding; IEA:UniProtKB-KW. GO:0003700; F:sequence-specific DNA binding transcription factor activity; TAS:ProtInc. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0051607; P:defense response to virus; IEA:UniProtKB-KW. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |