CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015752
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Putative ATP-dependent RNA helicase DHX30 
Protein Synonyms/Alias
 DEAH box protein 30 
Gene Name
 DHX30 
Gene Synonyms/Alias
 DDX30; KIAA0890 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
76NASRDLLKEFPQPKNubiquitination[1]
166NELFDAAKYRVLADRubiquitination[2]
Reference
 [1] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 
Functional Description
 Required for optimal function of the zinc-finger antiviral protein ZC3HAV1 (By similarity). Associates with mitochondrial DNA. 
Sequence Annotation
 DOMAIN 53 121 DRBM.
 DOMAIN 444 612 Helicase ATP-binding.
 DOMAIN 654 827 Helicase C-terminal.
 NP_BIND 457 464 ATP (By similarity).
 MOTIF 559 562 DEAH box.  
Keyword
 3D-structure; Alternative splicing; ATP-binding; Complete proteome; Cytoplasm; Helicase; Hydrolase; Mitochondrion; Mitochondrion nucleoid; Nucleotide-binding; Phosphoprotein; Reference proteome; RNA-binding. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1194 AA 
Protein Sequence
MAAARRLMAL AAGISPRLQP LGPRAAGRQG RSRGFSSSCA HPDHTKEAAE AESGMAPGGP 60
GEGDGSLVNA SRDLLKEFPQ PKNLLNSVIG RALGISHAKD KLVYVHTNGP KKKKVTLHIK 120
WPKSVEVEGY GSKKIDAERQ AAAAACQLFK GWGLLGPRNE LFDAAKYRVL ADRFGSPADS 180
WWRPEPTMPP TSWRQLNPES IRPGGPGGLS RSLGREEEED EEEELEEGTI DVTDFLSMTQ 240
QDSHAPLRDS RGSSFEMTDD DSAIRALTQF PLPKNLLAKV IQIATSSSTA KNLMQFHTVG 300
TKTKLSTLTL LWPCPMTFVA KGRRKAEAEN KAAALACKKL KSLGLVDRNN EPLTHAMYNL 360
ASLRELGETQ RRPCTIQVPE PILRKIETFL NHYPVESSWI APELRLQSDD ILPLGKDSGP 420
LSDPITGKPY VPLLEAEEVR LSQSLLELWR RRGPVWQEAP QLPVDPHRDT ILNAIEQHPV 480
VVISGDTGCG KTTRIPQLLL ERYVTEGRGA RCNVIITQPR RISAVSVAQR VSHELGPSLR 540
RNVGFQVRLE SKPPSRGGAL LFCTVGILLR KLQSNPSLEG VSHVIVDEVH ERDVNTDFLL 600
ILLKGLQRLN PALRLVLMSA TGDNERFSRY FGGCPVIKVP GFMYPVKEHY LEDILAKLGK 660
HQYLHRHRHH ESEDECALDL DLVTDLVLHI DARGEPGGIL CFLPGWQEIK GVQQRLQEAL 720
GMHESKYLIL PVHSNIPMMD QKAIFQQPPV GVRKIVLATN IAETSITIND IVHVVDSGLH 780
KEERYDLKTK VSCLETVWVS RANVIQRRGR AGRCQSGFAY HLFPRSRLEK MVPFQVPEIL 840
RTPLENLVLQ AKIHMPEKTA VEFLSKAVDS PNIKAVDEAV ILLQEIGVLD QREYLTTLGQ 900
RLAHISTDPR LAKAIVLAAI FRCLHPLLVV VSCLTRDPFS SSLQNRAEVD KVKALLSHDS 960
GSDHLAFVRA VAGWEEVLRW QDRSSRENYL EENLLYAPSL RFIHGLIKQF SENIYEAFLV 1020
GKPSDCTLAS AQCNEYSEEE ELVKGVLMAG LYPNLIQVRQ GKVTRQGKFK PNSVTYRTKS 1080
GNILLHKSTI NREATRLRSR WLTYFMAVKS NGSVFVRDSS QVHPLAVLLL TDGDVHIRDD 1140
GRRATISLSD SDLLRLEGDS RTVRLLKELR RALGRMVERS LRSELAALPP SVQEEHGQLL 1200
ALLAELLRGP CGSFDVRKTA DD 1222 
Gene Ontology
 GO:0042645; C:mitochondrial nucleoid; IDA:BHF-UCL.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0008026; F:ATP-dependent helicase activity; IEA:InterPro.
 GO:0003682; F:chromatin binding; IDA:UniProtKB.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW. 
Interpro
 IPR011545; DNA/RNA_helicase_DEAD/DEAH_N.
 IPR002464; DNA/RNA_helicase_DEAH_CS.
 IPR011709; DUF1605.
 IPR007502; Helicase-assoc_dom.
 IPR014001; Helicase_ATP-bd.
 IPR001650; Helicase_C.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00270; DEAD
 PF04408; HA2
 PF00271; Helicase_C
 PF07717; OB_NTP_bind 
SMART
 SM00487; DEXDc
 SM00847; HA2
 SM00490; HELICc 
PROSITE
 PS00690; DEAH_ATP_HELICASE
 PS50137; DS_RBD
 PS51192; HELICASE_ATP_BIND_1
 PS51194; HELICASE_CTER 
PRINTS