CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041349
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Tubulin polyglutamylase TTLL5 
Protein Synonyms/Alias
  
Gene Name
 TTLL5 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
118RTLSEAQKVNHFPRSubiquitination[1, 2]
180DRGPWIVKPVASSRGubiquitination[1]
258VRYDQGAKNIRNQFMubiquitination[1]
454SASDAEMKNLVGSARubiquitination[1]
467AREKGPGKLGGSVLGubiquitination[1]
826TFYTQKNKSASVFLGubiquitination[1]
840GTHSKISKNNNNYSDubiquitination[1]
851NYSDSGAKGDHPETIubiquitination[1]
889RFTTSAEKEAKLVYSubiquitination[1]
892TSAEKEAKLVYSNSSubiquitination[1]
1017AGSCYLNKHHSGIAKubiquitination[1]
1027SGIAKTQKEGEDASLubiquitination[1]
1037EDASLYSKRYNQSMVubiquitination[1]
1174LQQLEQQKLQSRQLLubiquitination[1]
1222SATASGQKPTTLPQKubiquitination[1, 2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1281 AA 
Protein Sequence
MPIVMARDLE ETASSSEDEE VISQEDHPCI MWTGGCRRIP VLVFHADAIL TKDNNIRVIG 60
ERYHLSYKIV RTDSRLVRSI LTAHGFHEVH PSSTDYNLMW TGSHLKPFLL RTLSEAQKVN 120
HFPRSYELTR KDRLYKNIIR MQHTHGFKAF HILPQTFLLP AEYAEFCNSY SKDRGPWIVK 180
PVASSRGRGV YLINNPNQIS LEENILVSRY INNPLLIDDF KFDVRLYVLV TSYDPLVIYL 240
YEEGLARFAT VRYDQGAKNI RNQFMHLTNY SVNKKSGDYV SCDDPEVEDY GNKWSMSAML 300
RYLKQEGRDT TALMAHVEDL IIKTIISAEL AIATACKTFV PHRSSCFELY GFDVLIDSTL 360
KPWLLEVNLS PSLACDAPLD LKIKASMISD MFTVVGFVCQ DPAQRASTRP IYPTFESSRR 420
NPFQKPQRPV SAQFQSSKAK QRCRPLSASD AEMKNLVGSA REKGPGKLGG SVLGLSMEEI 480
KVLRRVKEEN DRRGGFIRIF PTSETWEIYG SYLEHKTSMN YMLATRLFQD RMTADGAPEL 540
KIESLNSKAK LHAALYERKL LSLEVRKRRR RSSRLRAMRP KYPVITQPAE MNVKTETESE 600
EEEEVALDNE DEEQEASQEE SAGFLRENQA KYTPSLTALV ENTPKENSMK VREWNNKGGH 660
CCKLETQELE PKFNLMQILQ DNGNLSKMQA RIAFSAYLQH VQIRLMKDSG GQTFSASWAA 720
KEDEQMELVV RFLKRASNNL QHSLRMVLPS RRLALLERRR ILAHQLGDFI IVYNKETEQM 780
AEKKSKKKVE EEEEDGVNME NFQEFIRQAS EAELEEVLTF YTQKNKSASV FLGTHSKISK 840
NNNNYSDSGA KGDHPETIME EVKIKPPKQQ QTTEIHSDKL SRFTTSAEKE AKLVYSNSSS 900
GPTATLQKIP NTHLSSVTTS DLSPGPCHHS SLSQIPSAIP SMPHQPTILL NTVSASASPC 960
LHPGAQNIPS PTGLPRCRSG SHTIGPFSSF QSAAHIYSQK LSRPSSAKAA GSCYLNKHHS 1020
GIAKTQKEGE DASLYSKRYN QSMVTAELQR LAEKQAARQY SPSSHINLLT QQVTNLNLAT 1080
GIINRSSASA PPTLRPIISP SGPTWSTQSD PQAPENHSSS PGSRSLQTGG FAWEGEVENN 1140
VYSQATGVVP QHKYHPTAGS YQLQFALQQL EQQKLQSRQL LDQSRARHQA IFGSQTLPNS 1200
NLWTMNNGAG CRISSATASG QKPTTLPQKV VPPPSSCASL VPKPPPNHEQ VLRRATSQKA 1260
SNTRFRSSFQ NYLWYFFQAV S 1281 
Gene Ontology
 GO:0004835; F:tubulin-tyrosine ligase activity; IEA:InterPro.
 GO:0006464; P:cellular protein modification process; IEA:InterPro. 
Interpro
 IPR004344; Tub_tyr_ligase. 
Pfam
 PF03133; TTL 
SMART
  
PROSITE
 PS51221; TTL 
PRINTS