CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038668
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Voltage-dependent R-type calcium channel subunit alpha-1E 
Protein Synonyms/Alias
  
Gene Name
 Cacna1e 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
419EEEAFNQKHALQKAKubiquitination[1]
426KHALQKAKEVSPMSAubiquitination[1]
1136MEECSLEKNERACIDubiquitination[1]
1532QLDSELQKETLAIWPubiquitination[1]
1554DLLVPMPKASDLTVGubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Calcium; Calcium channel; Calcium transport; Complete proteome; Ion channel; Ion transport; Membrane; Reference proteome; Transmembrane; Transport; Voltage-gated channel. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1965 AA 
Protein Sequence
MEGWTTVLYN TNDALGATWN WLYFIPLIII GSFFVLNLVL GVLSGEFAKE RERVENRRAF 60
MKLRRQQQIE RELNGYRAWI DKAEEVMLAE ENKNSGTSAL EVLRRATIKR SRTEAMTRDS 120
SDEHCVDISS VGTPLARASI KSTKVDGASY FRHKERLLRI SIRHMVKSQV FYWIVLSVVA 180
LNTACVAIVH HNQPQWLTHL LYYAEFLFLG LFLLEMSLKM YGMGPRLYFH SSFNCFDFGV 240
TVGSIFEVVW AIFRPGTSFG ISVLRALRLL RIFKITKYWA SLRNLVVSLM SSMKSIISLL 300
FLLFLFIVVF ALLGMQLFGG RFNFNDGTPS ANFDTFPAAI MTVFQILTGE DWNEVMYNGI 360
RSQGGVSSGM WSAIYFIVLT LFGNYTLLNV FLAIAVDNLA NAQELTKDEQ EEEEAFNQKH 420
ALQKAKEVSP MSAPNMPSIE RDRRRRHHMS MWEPRSSHLR ERRRRHHMSV WEQRTSQLRR 480
HMQMSSQEAL NKEEAPPMNP LNPLNPLSPL NPLNAHPSLY RRPRPIEGLA LGLGLEKCEE 540
ERISRGGSLK GDIGGLTSAL DNQRSPLSLG KREPPWLPRS CHGNCDPIQQ EAGGGETVVT 600
FEDRARHRQS QRRSRHRRVR TEGKDSASAS RSRSASQERS LDEGVSVEGE KEHEPHSSHR 660
SKEPTIHEEE RTQDLRRTNS LMVPRGSGLV GALDEAETPL VQPQPELEVG KDAALTEQEA 720
EGSSEQALLG DVQLDVGRGI SQSEPDLSCM TANMDKATTE STSVTVAIPD VDPLVDSTVV 780
NISNKTDGEA SPLKEAETKE EEEEVEKKKK QKKEKRETGK AMVPHSSMFI FSTTNPIRRA 840
CHYIVNLRYF EMCILLVIAA SSIALAAEDP VLTNSERNKV LRYFDYVFTG VFTFEMVIKM 900
IDQGLILQDG SYFRDLWNIL DFVVVVGALV AFALANAIRT NKGRDIKTIK SLRVLRVLRP 960
LKTIKRLPKL KAVFDCVVTS LKNVFNILIV YKLFMFIFAV IAVQLFKGKF FYCTDSSKDT 1020
EKECIGNYVD HEKNKMEVKG REWKRHEFHY DNIIWALLTL FTVSTGEGWP QVLQHSVDVT 1080
EEDRGPSRSN RMEMSIFYVV YFVVFPFFFV NIFVALIIIT FQEQGDKMME ECSLEKNERA 1140
CIDFAISAKP LTRYMPQNRH TFQYRVWHFV VSPSFEYTIM AMIALNTVVL MMKYYSAPCT 1200
YELALKYLNI AFTMVFSLEC VLKVIAFGFL NYFRDTWNIF DFITVIGSIT EIILTDSKLV 1260
NTSGFNMSFL KLFRAARLIK LLRQGYTIRI LLWTFVQSFK ALPYVCLLIA MLFFIYAIIG 1320
MQVFGNIKLD EESHINRHNN FRSFFGSLML LFRSATGEAW QEIMLSCLGE KGCEPDTTAP 1380
SGQNESERCG TDLAYVYFVS FIFFCSFLML NLFVAVIMDN FEYLTRDSSI LGPHHLDEFV 1440
RVWAEYDRAA CGRIHYTEMY EMLTLMSPPL GLGKRCPSKV AYKRLVLMNM PVAEDMTVHF 1500
TSTLMALIRT ALDIKIAKGG ADRQQLDSEL QKETLAIWPH LSQKMLDLLV PMPKASDLTV 1560
GKIYAAMMIM DYYKQSKVKK QRQQLEEQKN APMFQRMEPS SLPQEIIANA KALPYLQQDP 1620
VSGLSGRSGY PSMSPLSPQE IFQLACMDPA DDGQFQEQQS LVVTDPSSMR RSFSTIRDKR 1680
SNSSWLEEFS MERSSENTYK SRRRSYHSSL RLSAHRLNSD SGHKSDTHRS GGRERGRSKE 1740
RKHLLSPDVS RCNSEERGTQ ADWESPERRQ SRSPSEGRSQ TPNRQGTGSL SESSIPSISD 1800
TSTPRRSRRQ LPPVPPKPRP LLSYSSLMRH TGGISPPPDG SEGGSPLASQ ALESNSACLT 1860
ESSNSLHPQQ GQHPSPQHYI SEPYLALHED SHASDCGEEE TLTFEAAVAT SLGRSNTIGS 1920
APPLRHSWQM PNGHYRRRRR GGPGPGMMCG AVSDLLSDTE EDDKC 1965 
Gene Ontology
 GO:0005891; C:voltage-gated calcium channel complex; TAS:MGI.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0005245; F:voltage-gated calcium channel activity; IMP:MGI.
 GO:0001662; P:behavioral fear response; IMP:MGI.
 GO:0048266; P:behavioral response to pain; IMP:MGI.
 GO:0042593; P:glucose homeostasis; IMP:MGI.
 GO:0007626; P:locomotory behavior; IMP:MGI.
 GO:0002027; P:regulation of heart rate; IMP:MGI.
 GO:0061178; P:regulation of insulin secretion involved in cellular response to glucose stimulus; IMP:MGI.
 GO:0090273; P:regulation of somatostatin secretion; IMP:MGI.
 GO:0019233; P:sensory perception of pain; IMP:MGI.
 GO:0030317; P:sperm motility; IMP:MGI.
 GO:0019226; P:transmission of nerve impulse; IMP:MGI.
 GO:0008542; P:visual learning; IMP:MGI. 
Interpro
 IPR002048; EF_hand_dom.
 IPR005821; Ion_trans_dom.
 IPR027359; K_channel_four-helix_dom.
 IPR014873; VDCC_a1su_IQ.
 IPR005449; VDCC_R_a1su.
 IPR002077; VDCCAlpha1. 
Pfam
 PF08763; Ca_chan_IQ
 PF00520; Ion_trans 
SMART
 SM01062; Ca_chan_IQ 
PROSITE
 PS50222; EF_HAND_2 
PRINTS
 PR00167; CACHANNEL.
 PR01633; RVDCCALPHA1.