Tag | Content |
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CPLM ID | CPLM-021045 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Protein XRP2 |
Protein Synonyms/Alias | |
Gene Name | Rp2 |
Gene Synonyms/Alias | Rp2h |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
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22 | EGEEEQPKLYSWDQR | ubiquitination | [1] | 265 | GFSLVQTKEMSMKTE | ubiquitination | [1] |
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Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Acts as a GTPase-activating protein (GAP) involved in trafficking between the Golgi and the ciliary membrane. Involved in localization of proteins, such as NPHP3, to the cilium membrane by inducing hydrolysis of GTP ARL3, leading to the release of UNC119 (or UNC119B). Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization. Acts as guanine nucleotide dissociation inhibitor towards ADP-ribosylation factor-like proteins. |
Sequence Annotation | DOMAIN 21 176 C-CAP/cofactor C-like. NP_BIND 95 96 GTP (By similarity). NP_BIND 112 115 GTP (By similarity). LIPID 2 2 N-myristoyl glycine (By similarity). LIPID 3 3 S-palmitoyl cysteine (By similarity). |
Keyword | Alternative splicing; Cell membrane; Cell projection; Cilium; Complete proteome; GTP-binding; GTPase activation; Lipoprotein; Membrane; Myristate; Nucleotide-binding; Palmitate; Protein transport; Reference proteome; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 347 AA |
Protein Sequence | MGCCFTKRRK SEKAEGEEEQ PKLYSWDQRE KVDPKDYMFS GLKDETVGRL PGKVAGQQFV 60 IQDCENCNIY IFDHSATITI DDCTNCVIFL GPVKGSVFFR NCRDCKCTLA CQQFRVRDCR 120 KLEVFLCCAT QPIIESSTNI KFGCFQWYYP ELAAQFKDAG LSIFNNIWSH VHDFTPVSGE 180 LNWSLLPENA VVQDYVPIPM TEEFKAVRIS TEANRSIVPV SRGQRQKYSD ESCLVVLFAD 240 DYTTANARKL IDEMVGKGFS LVQTKEMSMK TEDAQRVFQE KASDFLLLLN KGPVIALEFN 300 GDDAVQECHL IVNGMFNGTK VLGMEPRTLL GKKTECQKVW MACQAQTIVT ELQCQKRALD 360 PLNCGYKWL 369 |
Gene Ontology | GO:0005929; C:cilium; IEA:UniProtKB-SubCell. GO:0005737; C:cytoplasm; ISS:UniProtKB. GO:0005886; C:plasma membrane; ISS:UniProtKB. GO:0005524; F:ATP binding; IEA:InterPro. GO:0005525; F:GTP binding; IEA:UniProtKB-KW. GO:0005096; F:GTPase activator activity; ISS:UniProtKB. GO:0004550; F:nucleoside diphosphate kinase activity; IEA:InterPro. GO:0000902; P:cell morphogenesis; IEA:InterPro. GO:0006241; P:CTP biosynthetic process; IEA:InterPro. GO:0006183; P:GTP biosynthetic process; IEA:InterPro. GO:0015031; P:protein transport; IEA:UniProtKB-KW. GO:0006228; P:UTP biosynthetic process; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |