| Tag | Content |
|---|
| CPLM ID | CPLM-010541 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Histone H2A |
Protein Synonyms/Alias | |
Gene Name | His2A; His2A:CG31618; His2A:CG33808; His2A:CG33814; His2A:CG33817; His2A:CG33820; His2A:CG33823; His2A:CG33826; His2A:CG33829; His2A:CG33832; His2A:CG33835; His2A:CG33838; His2A:CG33841; His2A:CG33844; His2A:CG33847; His2A:CG33850; His2A:CG33862; His2A:CG33865 |
Gene Synonyms/Alias | H2a; CG31618; CG33808; CG33814; CG33817; CG33820; CG33823; CG33826; CG33829; CG33832; CG33835; CG33838; CG33841; CG33844; CG33847; CG33850; CG33862; CG33865 |
Created Date | July 27, 2013 |
Organism | Drosophila melanogaster (Fruit fly) |
NCBI Taxa ID | 7227 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 6 | **MSGRGKGGKVKGK | acetylation | [1] | | 9 | SGRGKGGKVKGKAKS | acetylation | [1] |
|
Reference | [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation. Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C. Sci Signal. 2011 Jul 26;4(183):ra48. [ PMID: 21791702] |
Functional Description | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
Sequence Annotation | MOD_RES 2 2 N-acetylserine (By similarity).
MOD_RES 2 2 Phosphoserine (Probable).
MOD_RES 120 120 Phosphothreonine.
CROSSLNK 119 119 Glycyl lysine isopeptide (Lys-Gly) |
Keyword | 3D-structure; Acetylation; Chromosome; Complete proteome; Direct protein sequencing; DNA-binding; Isopeptide bond; Nucleosome core; Nucleus; Phosphoprotein; Reference proteome; Ubl conjugation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 124 AA |
Protein Sequence | MSGRGKGGKV KGKAKSRSNR AGLQFPVGRI HRLLRKGNYA ERVGAGAPVY LAAVMEYLAA 60
EVLELAGNAA RDNKKTRIIP RHLQLAIRND EELNKLLSGV TIAQGGVLPN IQAVLLPKKT 120
EKKA 124 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |