CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037422
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Coiled-coil domain-containing protein 18 
Protein Synonyms/Alias
  
Gene Name
 CCDC18 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
63PNPSRSEKLILDVQPubiquitination[1]
86SPYENVCKISGSSTDubiquitination[2]
96GSSTDFQKKPRDKMFubiquitination[1, 3]
101FQKKPRDKMFSSSAPubiquitination[1]
638CLAFEKAKKIHLEQHubiquitination[1]
1117KEMESVMKEQEQYIAmethylation[4]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] Large-scale global identification of protein lysine methylation in vivo.
 Cao XJ, Arnaudo AM, Garcia BA.
 Epigenetics. 2013 May 1;8(5):477-85. [PMID: 23644510
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1299 AA 
Protein Sequence
MESSSSDYYN KDNEEESLLA NVASLRHELK ITEWSLQSLG EELSSVSPSE NSDYAPNPSR 60
SEKLILDVQP SHPGLLNYSP YENVCKISGS STDFQKKPRD KMFSSSAPVD QEIKSLREKL 120
NKLRQQNACL VTQNHSLMTK FESIHFELTQ SRAKVSMLES AQQQAASVPI LEEQIINLEA 180
EVSAQDKVLR EAENKLEQSQ KMVIEKEQSL QESKEECIKL KVDLLEQTKQ GKRAERQRNE 240
ALYNAEELSK AFQQYKKKVA EKLEKVQAEE EILERNLTNC EKENKRLQER CGLYKSELEI 300
LKEKLRQLKE ENNNGKEKLR IMAVKNSEVM AQLTESRQSI LKLESELENK DEILRDKFSL 360
MNENRELKVR VAAQNERLDL CQQEIESSRV ELRSLEKIIS QLPLKRELFG FKSYLSKYQM 420
SSFSNKEDRC IGCCEANKLV ISELRIKLAI KEAEIQKLHA NLTANQLSQS LITCNDSQES 480
SKLSSLETEP VKLGGHQVAE SVKDQNQHTM NKQYEKERQR LVTGIEELRT KLIQIEAENS 540
DLKVNMAHRT SQFQLIQEEL LEKASNSSKL ESEMTKKCSQ LLTLEKQLEE KIVAYSSIAA 600
KNAELEQELM EKNEKIRSLE TNINTEHEKI CLAFEKAKKI HLEQHKEMEK QIERLEAQLE 660
KKDQQFKEQE KTMSMLQQDI ICKQHHLESL DRLLTESKGE MKKENMKKDE ALKALQNQVS 720
EETIKVRQLD SALEICKEEL VLHLNQLEGN KEKFEKQLKK KSEEVYCLQK ELKIKNHSLQ 780
ETSEQNVILQ HTLQQQQQML QQETIRNGEL EDTQTKLEKQ VSKLEQELQK QRESSAEKLR 840
KMEEKCESAA HEADLKRQKV IELTGTARQV KIEMDQYKEE LSKMEKEIMH LKRDGENKAM 900
HLSQLDMILD QTKTELEKKT NAVKELEKLQ HSTETELTEA LQKREVLETE LQNAHGELKS 960
TLRQLQELRD VLQKAQLSLE EKYTTIKDLT AELRECKMEI EDKKQELLEM DQALKERNWE 1020
LKQRAAQVTH LDMTIREHRG EMEQKIIKLE GTLEKSELEL KECNKQIESL NDKLQNAKEQ 1080
LREKEFIMLQ NEQEISQLKK EIERTQQRMK EMESVMKEQE QYIATQYKEA IDLGQELRLT 1140
REQVQNSHTE LAEARHQQVQ AQREIERLSS ELEDMKQLSK EKDAHGNHLA EELGASKVRE 1200
AHLEARMQAE IKKLSAEVES LKEAYHMEMI SHQENHAKWK ISADSQKSSV QQLNEQLEKA 1260
KLELEEAQDT VSNLHQQVQD RNEVIEAANE ALLTKGENV 1299 
Gene Ontology
  
Interpro
  
Pfam
  
SMART
  
PROSITE
  
PRINTS