CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-012662
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Coiled-coil domain-containing protein 6 
Protein Synonyms/Alias
 Papillary thyroid carcinoma-encoded protein; Protein H4 
Gene Name
 CCDC6 
Gene Synonyms/Alias
 D10S170; TST1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
71ASLQQENKVLKIELEubiquitination[1]
118FISNTLFKKIQALQKubiquitination[2]
148LTNELSRKLMQLQHEubiquitination[3]
188LENDTISKQLTLEQLubiquitination[1, 4]
266MRHIRFLKNEVERLKubiquitination[5]
Reference
 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [5] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
  
Sequence Annotation
 REPEAT 106 134 1.
 REPEAT 135 163 2.
 REPEAT 164 192 3.
 REPEAT 193 206 4; approximate.
 REPEAT 207 235 5.
 REGION 106 235 5 X 29 AA tandem repeats.
 MOTIF 442 451 SH3-binding (Potential).
 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 52 52 Phosphoserine.
 MOD_RES 240 240 Phosphoserine.
 MOD_RES 244 244 Phosphoserine.
 MOD_RES 249 249 Phosphoserine.
 MOD_RES 254 254 Phosphoserine.
 MOD_RES 284 284 Phosphoserine.
 MOD_RES 323 323 Phosphoserine.
 MOD_RES 325 325 Phosphoserine.
 MOD_RES 349 349 Phosphothreonine.
 MOD_RES 363 363 Phosphoserine.
 MOD_RES 367 367 Phosphoserine.  
Keyword
 Acetylation; Chromosomal rearrangement; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Phosphoprotein; Polymorphism; Proto-oncogene; Reference proteome; Repeat; SH3-binding. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 474 AA 
Protein Sequence
MADSASESDT DGAGGNSSSS AAMQSSCSST SGGGGGGGGG GGGGKSGGIV ISPFRLEELT 60
NRLASLQQEN KVLKIELETY KLKCKALQEE NRDLRKASVT IQARAEQEEE FISNTLFKKI 120
QALQKEKETL AVNYEKEEEF LTNELSRKLM QLQHEKAELE QHLEQEQEFQ VNKLMKKIKK 180
LENDTISKQL TLEQLRREKI DLENTLEQEQ EALVNRLWKR MDKLEAEKRI LQEKLDQPVS 240
APPSPRDISM EIDSPENMMR HIRFLKNEVE RLKKQLRAAQ LQHSEKMAQY LEEERHMREE 300
NLRLQRKLQR EMERREALCR QLSESESSLE MDDERYFNEM SAQGLRPRTV SSPIPYTPSP 360
SSSRPISPGL SYASHTVGFT PPTSLTRAGM SYYNSPGLHV QHMGTSHGIT RPSPRRSNSP 420
DKFKRPTPPP SPNTQTPVQP PPPPPPPPMQ PTVPSAATSQ PTPSQHSAHP SSQP 474 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
 GO:0005200; F:structural constituent of cytoskeleton; TAS:ProtInc. 
Interpro
 IPR019152; DUF2046. 
Pfam
 PF09755; DUF2046 
SMART
  
PROSITE
  
PRINTS