UniProt Accession

 SMG9_HUMAN; Q9H0W8; O60429; Q9H9A9 

Genbank Protein ID

 AL136606; AK022948; AC004780; BC008869 

Genbank Nucleotide ID

 CAB66541.1; BAB14323.1; AAC17932.1; AAH08869.1 

Protein Name

 Protein SMG9 

Protein Synonyms/Alias

 Protein smg-9 homolog 

Gene Name

 SMG9 

Gene Synonyms/Alias

 C19orf61 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
170	DPVVGQAKLLPPERM	ubiquitination	[1]
373	HLVFLQNKARREDFC	ubiquitination	[1, 2]
472	SFQSLVSKLRSQVMS	ubiquitination	[1, 3]
508	RIWDGVRKSSALAEY	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 

Functional Description

 Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG8 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required for the efficient association between SMG1 and SMG8. 

Sequence Annotation

 MOD_RES 2 2 N-acetylserine.
 MOD_RES 7 7 Phosphoserine.
 MOD_RES 32 32 Phosphoserine.
 MOD_RES 53 53 Phosphoserine.
 MOD_RES 451 451 Phosphoserine.  

Keyword

 Acetylation; Alternative splicing; Complete proteome; Nonsense-mediated mRNA decay; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 520 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0010467; P:gene expression; TAS:Reactome.
 GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IMP:UniProtKB. 

Interpro

 IPR019354; Smg8/Smg9. 

Pfam

 PF10220; DUF2146 

SMART

  

PROSITE

  

PRINTS