UniProt Accession

 CERS1_HUMAN; P27544 

Genbank Protein ID

 M62302; AF105009; AF105005; AF105006; AF105007; AF105008; AC005197; AC003972; BC022450 

Genbank Nucleotide ID

 AAA58500.1; AAD16892.1; AAD16892.1; AAD16892.1; AAD16892.1; AAD16892.1; AAC24611.1; AAH22450.1 

Protein Name

 Ceramide synthase 1 

Protein Synonyms/Alias

 CerS1; LAG1 longevity assurance homolog 1; Longevity assurance gene 1 protein homolog 1; Protein UOG-1 

Gene Name

 CERS1 

Gene Synonyms/Alias

 LAG1; LASS1; UOG1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
98	LQPRDAAKMPESAWK	ubiquitination	[1]
226	TKLNIYFKSRGGSYH	ubiquitination	[1]
318	TGQVHELKDLREYDT	ubiquitination	[2, 3]
332	TAEAQSLKPSKAEKP	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 May be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing mainly one fatty acid donor (N-linked stearoyl- (C18) ceramide) in a fumonisin B1-independent manner (By similarity). 

Sequence Annotation

 DOMAIN 97 311 TLC.  

Keyword

 Alternative splicing; Complete proteome; Endoplasmic reticulum; Golgi apparatus; Lipid biosynthesis; Lipid metabolism; Membrane; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 350 AA 

Protein Sequence

Gene Ontology

 GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.
 GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0050291; F:sphingosine N-acyltransferase activity; ISS:HGNC.
 GO:0046513; P:ceramide biosynthetic process; ISS:HGNC.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome. 

Interpro

 IPR016439; Longevity_assurance_LAG1_LAC1.
 IPR006634; TLC-dom. 

Pfam

 PF03798; TRAM_LAG1_CLN8 

SMART

 SM00724; TLC 

PROSITE

 PS50922; TLC 

PRINTS