UniProt Accession

 GLYC_HUMAN; P34896; D3DXD0; Q96HY0; Q9UMD1; Q9UMD2 

Genbank Protein ID

 L11931; L23928; L23928; L23928; Y14485; Y14486; Y14487; CH471196; CH471196; CH471196; BC007979; BC022874; BC038598 

Genbank Nucleotide ID

 AAA63257.1; AAA36020.1; AAA36019.1; AAA36018.1; CAB54838.1; CAB54839.1; CAB54840.1; EAW55637.1; EAW55640.1; EAW55641.1; AAH07979.1; AAH22874.1; AAH38598.1 

Protein Name

 Serine hydroxymethyltransferase, cytosolic 

Protein Synonyms/Alias

 SHMT; Glycine hydroxymethyltransferase; Serine methylase 

Gene Name

 SHMT1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
173	FFESMPYKVNPDTGY	ubiquitination	[1]
271	AGMIFYRKGVAVALK	acetylation	[2, 3]
377	TSRGLLEKDFQKVAH	ubiquitination	[1]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [3] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773] 

Functional Description

 Interconversion of serine and glycine. 

Sequence Annotation

 MOD_RES 34 34 Phosphotyrosine (By similarity).
 MOD_RES 257 257 N6-(pyridoxal phosphate)lysine.  

Keyword

 3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; One-carbon metabolism; Phosphoprotein; Polymorphism; Pyridoxal phosphate; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 483 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:UniProtKB.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0016597; F:amino acid binding; IEA:Compara.
 GO:0004372; F:glycine hydroxymethyltransferase activity; IDA:UniProtKB.
 GO:0008732; F:L-allo-threonine aldolase activity; IEA:Compara.
 GO:0042803; F:protein homodimerization activity; IDA:UniProtKB.
 GO:0030170; F:pyridoxal phosphate binding; IDA:UniProtKB.
 GO:0045329; P:carnitine biosynthetic process; TAS:Reactome.
 GO:0046655; P:folic acid metabolic process; IDA:UniProtKB.
 GO:0019264; P:glycine biosynthetic process from serine; IEA:Compara.
 GO:0006565; P:L-serine catabolic process; IDA:UniProtKB.
 GO:0051289; P:protein homotetramerization; IEA:Compara.
 GO:0051262; P:protein tetramerization; IDA:UniProtKB.
 GO:0009113; P:purine nucleobase biosynthetic process; IDA:UniProtKB.
 GO:0035999; P:tetrahydrofolate interconversion; IEA:UniProtKB-UniPathway. 

Interpro

 IPR015424; PyrdxlP-dep_Trfase.
 IPR015421; PyrdxlP-dep_Trfase_major_sub1.
 IPR015422; PyrdxlP-dep_Trfase_major_sub2.
 IPR001085; Ser_HO-MeTrfase.
 IPR019798; Ser_HO-MeTrfase_PLP_BS. 

Pfam

 PF00464; SHMT 

SMART

  

PROSITE

 PS00096; SHMT 

PRINTS