UniProt Accession

 B2MWM9_MOUSE; B2MWM9 

Genbank Protein ID

 EU639407; CH466525 

Genbank Nucleotide ID

 ACC77467.1; EDL10961.1 

Protein Name

 Calreticulin 

Protein Synonyms/Alias

 MCG5893 

Gene Name

 Calr 

Gene Synonyms/Alias

 mCG_5893 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
55	KFVLSSGKFYGDLEK	ubiquitination	[1]
62	KFYGDLEKDKGLQTS	ubiquitination	[1]
80	RFYALSAKFEPFSNK	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

  

Sequence Annotation

  

Keyword

 Chaperone; Endoplasmic reticulum. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 416 AA 

Protein Sequence

Gene Ontology

 GO:0001669; C:acrosomal vesicle; IEA:Compara.
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0005783; C:endoplasmic reticulum; IDA:MGI.
 GO:0005788; C:endoplasmic reticulum lumen; IEA:Compara.
 GO:0009897; C:external side of plasma membrane; IDA:MGI.
 GO:0031012; C:extracellular matrix; IEA:Compara.
 GO:0005615; C:extracellular space; IDA:MGI.
 GO:0005794; C:Golgi apparatus; IEA:Compara.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:Compara.
 GO:0016529; C:sarcoplasmic reticulum; IEA:Compara.
 GO:0005509; F:calcium ion binding; IDA:MGI.
 GO:0042562; F:hormone binding; IEA:Compara.
 GO:0005506; F:iron ion binding; IEA:Compara.
 GO:0003729; F:mRNA binding; IEA:Compara.
 GO:0042277; F:peptide binding; IEA:Compara.
 GO:0055007; P:cardiac muscle cell differentiation; IEA:Compara.
 GO:0007050; P:cell cycle arrest; IEA:Compara.
 GO:0071285; P:cellular response to lithium ion; IEA:Compara.
 GO:0071310; P:cellular response to organic substance; IEA:Compara.
 GO:0090398; P:cellular senescence; IEA:Compara.
 GO:0030866; P:cortical actin cytoskeleton organization; IDA:MGI.
 GO:0033144; P:negative regulation of intracellular steroid hormone receptor signaling pathway; IEA:Compara.
 GO:0045665; P:negative regulation of neuron differentiation; IEA:Compara.
 GO:0048387; P:negative regulation of retinoic acid receptor signaling pathway; IEA:Compara.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0017148; P:negative regulation of translation; IEA:Compara.
 GO:0045787; P:positive regulation of cell cycle; IEA:Compara.
 GO:0008284; P:positive regulation of cell proliferation; IEA:Compara.
 GO:2000510; P:positive regulation of dendritic cell chemotaxis; IEA:Compara.
 GO:0045740; P:positive regulation of DNA replication; IEA:Compara.
 GO:1900026; P:positive regulation of substrate adhesion-dependent cell spreading; IEA:Compara.
 GO:0006611; P:protein export from nucleus; IEA:Compara.
 GO:0006457; P:protein folding; IEA:InterPro.
 GO:0034504; P:protein localization to nucleus; IEA:Compara.
 GO:0040020; P:regulation of meiosis; IDA:MGI.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0032355; P:response to estradiol stimulus; IEA:Compara.
 GO:0033574; P:response to testosterone stimulus; IEA:Compara.
 GO:0007283; P:spermatogenesis; IEA:Compara. 

Interpro

 IPR001580; Calret/calnex.
 IPR018124; Calret/calnex_CS.
 IPR009169; Calreticulin.
 IPR008985; ConA-like_lec_gl_sf.
 IPR013320; ConA-like_subgrp. 

Pfam

 PF00262; Calreticulin 

SMART

  

PROSITE

 PS00803; CALRETICULIN_1
 PS00804; CALRETICULIN_2
 PS00805; CALRETICULIN_REPEAT 

PRINTS

 PR00626; CALRETICULIN.