CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024342
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Chromodomain-helicase-DNA-binding protein 7 
Protein Synonyms/Alias
 CHD-7; ATP-dependent helicase CHD7 
Gene Name
 Chd7 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
676EPKEKKAKTVTPKPKacetylation[1]
681KAKTVTPKPKSSKKSacetylation[1]
Reference
 [1] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654] 
Functional Description
 Probable transcription regulator. Maybe involved in the in 45S precursor rRNA production (By similarity). 
Sequence Annotation
 DOMAIN 790 857 Chromo 1.
 DOMAIN 872 937 Chromo 2.
 DOMAIN 970 1144 Helicase ATP-binding.
 DOMAIN 1284 1454 Helicase C-terminal.
 NP_BIND 983 990 ATP (By similarity).
 MOTIF 1095 1098 DEAH box.
 MOD_RES 630 630 Phosphoserine (By similarity).
 MOD_RES 715 715 Phosphoserine (By similarity).
 MOD_RES 1567 1567 Phosphoserine (By similarity).
 MOD_RES 1571 1571 Phosphoserine (By similarity).
 MOD_RES 1864 1864 Phosphoserine (By similarity).
 MOD_RES 2220 2220 Phosphoserine (By similarity).
 MOD_RES 2222 2222 Phosphoserine (By similarity).
 MOD_RES 2226 2226 Phosphoserine (By similarity).
 MOD_RES 2240 2240 Phosphoserine (By similarity).
 MOD_RES 2261 2261 Phosphoserine (By similarity).
 MOD_RES 2264 2264 Phosphoserine (By similarity).
 MOD_RES 2345 2345 Phosphoserine (By similarity).
 MOD_RES 2384 2384 Phosphoserine (By similarity).
 MOD_RES 2461 2461 Phosphothreonine (By similarity).
 MOD_RES 2524 2524 Phosphoserine (By similarity).
 MOD_RES 2540 2540 Phosphothreonine (By similarity).
 MOD_RES 2548 2548 Phosphoserine (By similarity).
 MOD_RES 2608 2608 Phosphoserine (By similarity).
 MOD_RES 2945 2945 Phosphoserine (By similarity).  
Keyword
 Alternative splicing; ATP-binding; Chromatin regulator; Coiled coil; Complete proteome; DNA-binding; Helicase; Hydrolase; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Repeat; rRNA processing; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2986 AA 
Protein Sequence
MADPGMMSLF GEDGSLFSEG LEGLGECGYP ENPVNPMGQQ MPIDQGFPSL QPSLHHPSPN 60
QNQTKLTHFD HYSQYEQKMH LMDQPNRMMG SAPGNGLASP HSQYHTPPVP QVPHGGGGGG 120
QMGVYPGIQN ERHGQSFVDG GSMWGPRAVQ VPDQIRAPYQ QQQPQPAPSG PPAQGHPQHM 180
QQMGSYLARG DFSMQQHGQP QQRMGQFSQG QEGLSQGSPF IATSGPGHLS HMPQQSPSMA 240
PSLRHPVQQQ FHHHPAALHG ESVAHSPRFS PNPPQQGAVR PQTLNFSSRN QTVPSPTVNN 300
SGQYSRYPYS NLNQGLVNST GMNQNLGLTN STPMNQSVPR YPNAVGFPSN SGQGLVHQQP 360
IHSSGSLNQM NTQTMHPSQP QGTYASPPPM SPMKAMSNPA GTPPPQVRPG SAGMPMEVGS 420
YPNMPHPQPS HQPPGAMGIG QRNMGPRNMQ QPRSFMGMSS APRELTGHMR PNGCPGVGLA 480
DPQAIQERLI PGQQHPGQQP SFQQLPTCPP LQPHPGLHQS SPPHPHHQPW AQLHPSPQNT 540
PQKVPVHQHS PSEPFLEKPV PDMTQVSAQN AQLVKSDDYL PSIEQQPQQK KKKKKNNHIA 600
AGDSSKGFGK DDFPGGVENQ ELRRNSLDVS QEEKKKKKRP KVKKDPKESK EPKEKKEPKT 660
PKAPKIPKEP KEKKAKTVTP KPKSSKKSSN KKPDSEASAL KKKVNKGKTE GSENSDLDKT 720
PPPSPAPEED EDPGVQKRRS SRQVKRKRYT EDLEFKISDE EADDADAAGR DSPSNTSQSE 780
QQESVDAEGP VVEKIMSSRL VKKQKESGEE VEVEEFYVKY KNFSYLHCQW ASVEDLEKDK 840
RIQQKIKRFK SKQGQSKFLS EIEDDLFNPD YVEVDRIMDF ARSTDDRGEP VIHYLVKWCS 900
LPYEDSTWEL KQDIDQTKIE EFEKLMSREP ETERVERPPA DDWKKSESSR EYKNNNKLRE 960
YQLEGVNWLL FNWYNMRNCI LADEMGLGKT IQSITFLYEI YLKGIHGPFL VIAPLSTIPN 1020
WEREFRTWTE LNVVVYHGSQ ASRRTIQLYE MYFKDPQGRV IKGSYKFHAI ITTFEMILTD 1080
CPELRNIPWR CVVIDEAHRL KNRNCKLLEG LKMMDLEHKV LLTGTPLQNT VEELFSLLHF 1140
LEPSRFPSET TFMQEFGDLK TEEQVQKLQA ILKPMMLRRL KEDVEKNLAP KEETIIEVEL 1200
TNIQKKYYRA ILEKNFTFLS KGGGQANVPN LLNTMMELRK CCNHPYLING AEEKILEEFK 1260
ETHNAESPDF QLQAMIQAAG KLVLIDKLLP KLKAGGHRVL IFSQMVRCLD ILEDYLIQRR 1320
YPYERIDGRV RGNLRQAAID RFSKPDSDRF VFLLCTRAGG LGINLTAADT CIIFDSDWNP 1380
QNDLQAQARC HRIGQSKSVK IYRLITRNSY EREMFDKASL KLGLDKAVLQ SMSGRENATN 1440
GVQQLSKKEI EDLLRKGAYG ALMDEEDEGS KFCEEDIDQI LLRRTHTITI ESEGKGSTFA 1500
KASFVASGNR TDISLDDPNF WQKWAKKAEL DIDALNGRNN LVIDTPRVRK QTRLYSAVKE 1560
DELMEFSDLE SDSEEKPCAK PRRPQDKSQG YARSECFRVE KNLLVYGWGR WTDILSHGRY 1620
KRQLTEQDVE TICRAILVYC LNHYRGDENI KSFIWDLITP TADGQTRALL NHSGLSAPVP 1680
RGRKGKKVKA QSTQPVVHDA HWLASCNPDA LFQEDSYKKH LKHHCNKVLL RVRMLYYLRQ 1740
EVIGDQAEKI LEGADSSEAD VWIPEPFHAE VPTDWWDREA DKSLLIGVFK HGYEKYNSMR 1800
ADPALCFLER VGMPDAKAIA AEQRGTDMLA DGGDGGEFDR EDEDPEYKPT RAPFKDEIDE 1860
FANSPAEDKE ESMEVHSSGK HSESNAELGQ LYWPNTSTLT TRLRRLITAY QRSYKRQQMR 1920
QEALMKTDRR RRRPREEVRA LEAEREAIIS EKRQKWTRRE EADFYRVVST FGVIFDPVKQ 1980
QFDWNQFRAF ARLDKKSDES LGKYFSCFVA MCRRVCRMPA KPEDEPPDLA SLIEPITEER 2040
ASRTLYRIEL LRKIREQVLH HPQLSDRLKL CQPSLDLPEW WECGRHDRDL LVGAAKHGVS 2100
RTDYHILNDP ELSFLDAHKS FAQNRGASTV PPLNTLAMGF GQTPPVISSA HVHEEKAMEQ 2160
AEGKAEECEH SPAKERSDGK EEEEEAGGAK DGKQECEVEA SSVKGELKGV EGSADPGSKS 2220
VSEKGSEEDE EEKLEDDDKS EESSQPEAGA VSRGKTFDEE SNASLSTARD ETRDGFYMED 2280
GDASVAQLLH ERTFAFSFWP KDRVMINRLD NICEAVLKGK WPVNRRQMFD FQGLVPGYPP 2340
SAVDSPLQKR SFAELSMVSQ ASISASEDIT TSPQLSKDDA LNLSVPRQRR RRRRKVEIEA 2400
ERAAKRRNLM EMVAQLRESQ VVSENGQEKV VDLSKASREA TSSTSNFSSL TSKFILPNVS 2460
TPVSDAFKSQ MELLQAGLSR TPTRHMLNGS LVDGEPPMKR RRGRRKNVEG LDLLFMSHKR 2520
TPLSAEDAEV TKAFEEDIET PPIRNIPSPG QLDPDTRIPV INLEDGTRLV GEDAPKNKDL 2580
VDWLKLHPTY TVDMPSYVPK NTDVLFSSFQ KPKQKRHRCR NPNKLDINTL TGEERVPVVN 2640
KRNGKKMGGA MAPPMKDLPR WLEENPEFAV APDWTDIVKQ SGFVPESMFD RLLTGPVVRG 2700
EGASRRGRRP KSEIARAAAA AAAVASTSGI NPLLVNSLFA GMDLTSLQNL QNLQSLQLAG 2760
LMGFPPGLAT AATAGGDAKS PAAVLPLMLP GMAGLPNVFG LGGLLNNPLS AATGNTTTAS 2820
SQGEPEDGTS KAEEKGNDNE DENRDSEKST DTVSAADSAN GSVGAATAPA ALPSNPLAFN 2880
PFLLSTMAPG LFYPSMFLPP GLGGLTLPGF PALAGLQNAV GTSEEKAADK AEGGPCKDGE 2940
TLEGSDAEEN LDKTVESSIL EDEVAQGEEL DSLEGGDEIE NTGNDE 2986 
Gene Ontology
 GO:0005634; C:nucleus; ISS:UniProtKB.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0003682; F:chromatin binding; IEA:InterPro.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
 GO:0007512; P:adult heart development; IMP:MGI.
 GO:0007628; P:adult walking behavior; IMP:MGI.
 GO:0048844; P:artery morphogenesis; IGI:MGI.
 GO:0008015; P:blood circulation; IMP:MGI.
 GO:0043010; P:camera-type eye development; IMP:MGI.
 GO:0007417; P:central nervous system development; IEA:Compara.
 GO:0016568; P:chromatin modification; IEA:UniProtKB-KW.
 GO:0050890; P:cognition; IEA:Compara.
 GO:0021545; P:cranial nerve development; IEA:Compara.
 GO:0035116; P:embryonic hindlimb morphogenesis; IMP:MGI.
 GO:0060324; P:face development; IEA:Compara.
 GO:0030540; P:female genitalia development; IMP:MGI.
 GO:0003007; P:heart morphogenesis; IMP:MGI.
 GO:0001701; P:in utero embryonic development; IMP:MGI.
 GO:0043584; P:nose development; IMP:MGI.
 GO:0060021; P:palate development; IMP:MGI.
 GO:0040018; P:positive regulation of multicellular organism growth; IMP:MGI.
 GO:0060123; P:regulation of growth hormone secretion; IEA:Compara.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0060041; P:retina development in camera-type eye; IEA:Compara.
 GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
 GO:0048752; P:semicircular canal morphogenesis; IGI:MGI.
 GO:0007605; P:sensory perception of sound; IMP:MGI.
 GO:0001501; P:skeletal system development; IEA:Compara.
 GO:0030217; P:T cell differentiation; IEA:Compara.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR006576; BRK_domain.
 IPR023780; Chromo_domain.
 IPR000953; Chromo_domain/shadow.
 IPR016197; Chromodomain-like.
 IPR014001; Helicase_ATP-bd.
 IPR001650; Helicase_C.
 IPR027417; P-loop_NTPase.
 IPR001005; SANT/Myb.
 IPR000330; SNF2_N. 
Pfam
 PF07533; BRK
 PF00385; Chromo
 PF00271; Helicase_C
 PF00176; SNF2_N 
SMART
 SM00592; BRK
 SM00298; CHROMO
 SM00487; DEXDc
 SM00490; HELICc
 SM00717; SANT 
PROSITE
 PS00598; CHROMO_1
 PS50013; CHROMO_2
 PS00690; DEAH_ATP_HELICASE
 PS51192; HELICASE_ATP_BIND_1
 PS51194; HELICASE_CTER 
PRINTS