UniProt Accession

 RUVB2_MOUSE; Q9WTM5 

Genbank Protein ID

 AB013912 

Genbank Nucleotide ID

 BAA76297.1 

Protein Name

 RuvB-like 2 

Protein Synonyms/Alias

 p47 protein 

Gene Name

 Ruvbl2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
365	STSPYSEKDTKQILR	acetylation	[1, 2]

Reference

 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

 Possesses single-stranded DNA-stimulated ATPase and ATP- dependent DNA helicase (5' to 3') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity (By similarity). 

Sequence Annotation

 NP_BIND 77 84 ATP (By similarity).
 MOD_RES 2 2 N-acetylalanine (By similarity).  

Keyword

 Acetylation; Activator; ATP-binding; Chromatin regulator; Complete proteome; DNA damage; DNA recombination; DNA repair; Helicase; Hydrolase; Nucleotide-binding; Nucleus; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 463 AA 

Protein Sequence

Gene Ontology

 GO:0031011; C:Ino80 complex; IEA:Compara.
 GO:0071339; C:MLL1 complex; ISS:UniProtKB.
 GO:0035267; C:NuA4 histone acetyltransferase complex; ISS:UniProtKB.
 GO:0030529; C:ribonucleoprotein complex; IDA:MGI.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0043141; F:ATP-dependent 5'-3' DNA helicase activity; IEA:InterPro.
 GO:0003684; F:damaged DNA binding; IEA:InterPro.
 GO:0034644; P:cellular response to UV; IEA:Compara.
 GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
 GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
 GO:0043968; P:histone H2A acetylation; ISS:UniProtKB.
 GO:0043967; P:histone H4 acetylation; ISS:UniProtKB.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR003593; AAA+_ATPase.
 IPR004504; DNA_repair_RadA.
 IPR012340; NA-bd_OB-fold.
 IPR027417; P-loop_NTPase.
 IPR027238; RuvB-like.
 IPR010339; TIP49_C. 

Pfam

 PF06068; TIP49 

SMART

 SM00382; AAA 

PROSITE

  

PRINTS

 PR01874; DNAREPAIRADA.