UniProt Accession

 NGBR_HUMAN; Q96E22; B2RWQ4; O00251 

Genbank Protein ID

 Z98172; AL590303; AL590303; Z98172; CH471051; BC013026; BC063794; BC066910; BC110325; BC150654; BC150655; U82319 

Genbank Nucleotide ID

 CAI19895.1; CAI19895.1; CAH71370.1; CAH71370.1; EAW48201.1; AAH13026.1; AAH63794.1; AAH66910.1; AAI10326.1; AAI50655.1; AAI50656.1; AAB72234.1 

Protein Name

 Nogo-B receptor 

Protein Synonyms/Alias

 NgBR; Nuclear undecaprenyl pyrophosphate synthase 1 homolog 

Gene Name

 NUS1 

Gene Synonyms/Alias

 C6orf68; NGBR 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
154	RLMDEILKQQQELLG	ubiquitination	[1]
197	VLSPEDGKADIVRAA	ubiquitination	[1]
216	QLVAQKQKRPTDLDV	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Acts as a specific receptor for the N-terminus of Nogo- B, a neural and cardiovascular regulator. Regulates the stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol. 

Sequence Annotation

 CARBOHYD 144 144 N-linked (GlcNAc...).
 CARBOHYD 271 271 N-linked (GlcNAc...).  

Keyword

 Angiogenesis; Complete proteome; Developmental protein; Differentiation; Endoplasmic reticulum; Glycoprotein; Membrane; Polymorphism; Receptor; Reference proteome; Signal; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 293 AA 

Protein Sequence

Gene Ontology

 GO:0005789; C:endoplasmic reticulum membrane; IDA:MGI.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0016765; F:transferase activity, transferring alkyl or aryl (other than methyl) groups; IEA:InterPro.
 GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.
 GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
 GO:0032367; P:intracellular cholesterol transport; IGI:MGI.
 GO:0006486; P:protein glycosylation; IEA:UniProtKB-UniPathway.
 GO:0055092; P:sterol homeostasis; IEA:Compara. 

Interpro

 IPR001441; UPP_synth-like. 

Pfam

 PF01255; Prenyltransf 

SMART

  

PROSITE

 PS01066; UPP_SYNTHASE 

PRINTS