CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039692
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Endonuclease ZRANB3 
Protein Synonyms/Alias
  
Gene Name
 ZRANB3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
36LPDRLRAKLLPFQKDubiquitination[1]
42AKLLPFQKDGIIFALubiquitination[1]
50DGIIFALKRNGSRIDubiquitination[1]
116EINVIQNKTDVRRMSubiquitination[1]
163VDESHYMKSRNATRSubiquitination[1]
179ILLPIVQKARRAILLubiquitination[1]
218GRWTDYAKRYCNAHIubiquitination[1]
230AHIRYFGKRPQWDCRubiquitination[1]
283DLPSAAAKELNTSFEubiquitination[1, 2]
327IAKAGAVKDYIKMMLubiquitination[1]
386HLVNQFQKDPDTRVAubiquitination[1]
518FTHFEKEKQHDIRSFubiquitination[1]
543MTSCDESKRFREENTubiquitination[1]
558VVSSDPTKTAARDIIubiquitination[1]
579EPETKRLKLAASEDHubiquitination[1]
598EETPSQSKQIRTPLVubiquitination[1, 3]
677SQKDTSKKVQTISDCubiquitination[1]
748DRIHIYTKDGKQMSCubiquitination[1]
803MKQRIIRKSGQLFCSubiquitination[1]
820LALEEITKQQTKQNCubiquitination[1]
834CTKRYITKEDVAVASubiquitination[1]
921QQPTCQTKQACKANSubiquitination[1]
925CQTKQACKANSWDSRubiquitination[1]
954NNSYLRAKVFETEHGubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1077 AA 
Protein Sequence
MPRVHNIKKS LTPHISCVTN ESDNLLDFLP DRLRAKLLPF QKDGIIFALK RNGSRIDCDQ 60
MGLGKTIQAI GITYFYKEEW PLLIVVPSSL RYPWTEEIEK WIPELSPEEI NVIQNKTDVR 120
RMSTSKVTVL GYGLLTADAK TLIDALNNQN FKVVIVDESH YMKSRNATRS RILLPIVQKA 180
RRAILLTGTP ALGRPEELFM QIEALFPQKF GRWTDYAKRY CNAHIRYFGK RPQWDCRGAS 240
NLNELHQLLS DIMIRRLKTE VLTQLPPKVR QRIPFDLPSA AAKELNTSFE EWEKIMRTPN 300
SGAMETVMGL ITRMFKQTAI AKAGAVKDYI KMMLQNDSLK FLVFAHHLSM LQACTEAVIE 360
NKTRYIRIDG SVSSSERIHL VNQFQKDPDT RVAILSIQAA GQGLTFTAAS HVVFAELYWD 420
PGHIKQAEDR AHRIGQCSSV NIHYLIANGT LDTLMWGMLN RKAQVTGSTL NGRKEKIQAE 480
EGDKEKWDFL QFAEAWTPND SSEELRKEAL FTHFEKEKQH DIRSFFVPQP KKRQLMTSCD 540
ESKRFREENT VVSSDPTKTA ARDIIDYESD VEPETKRLKL AASEDHCSPS EETPSQSKQI 600
RTPLVESVQE AKAQLTTPAF PVEGWQCSLC TYINNSELPY CEMCETPQGS AVMQIDSLNH 660
IQDKNEKDDS QKDTSKKVQT ISDCEKQALA QSEPGQLADS KEETPKIEKE DGLTSQPEQW 720
KSSDTLPVYD TLMFCASRNT DRIHIYTKDG KQMSCNFIPL DIKLDLWEDL PASFQLKQYR 780
SLILRFVREW SSLTAMKQRI IRKSGQLFCS PILALEEITK QQTKQNCTKR YITKEDVAVA 840
SMDKVKNVGG HVRLITKESR PRDPFTKKLL EDGACVPFLN PYTVQADLTV KPSTSKGYLQ 900
AVDNEGNPLC LRCQQPTCQT KQACKANSWD SRFCSLKCQE EFWIRSNNSY LRAKVFETEH 960
GVCQLCNVNA QELFLRLRDA PKSQRKNLLY ATWTSKLPLE QLNEMIRNPG EGHFWQVDHI 1020
KPVYGGGGQC SLDNLQTLCT VCHKERTARQ AKERSQVRRQ SLASKHGSDI TRFLVKK 1077 
Gene Ontology
 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0004519; F:endonuclease activity; IEA:InterPro.
 GO:0004386; F:helicase activity; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro. 
Interpro
 IPR014001; Helicase_ATP-bd.
 IPR001650; Helicase_C.
 IPR002711; HNH.
 IPR003615; HNH_nuc.
 IPR027417; P-loop_NTPase.
 IPR000330; SNF2_N.
 IPR001876; Znf_RanBP2. 
Pfam
 PF00271; Helicase_C
 PF01844; HNH
 PF00176; SNF2_N
 PF00641; zf-RanBP 
SMART
 SM00487; DEXDc
 SM00490; HELICc
 SM00507; HNHc
 SM00547; ZnF_RBZ 
PROSITE
 PS51192; HELICASE_ATP_BIND_1
 PS51194; HELICASE_CTER
 PS01358; ZF_RANBP2_1
 PS50199; ZF_RANBP2_2 
PRINTS