UniProt Accession

 PR38B_MOUSE; Q80SY5; Q9CTD9; Q9CU48; Q9CUI6 

Genbank Protein ID

 AK003895; AK015938; AK018126; AL671894; BC050900; BC052077 

Genbank Nucleotide ID

 BAB23062.1; BAB30042.1; BAB31082.1; CAM20607.1; AAH50900.1; AAH52077.1 

Protein Name

 Pre-mRNA-splicing factor 38B 

Protein Synonyms/Alias

  

Gene Name

 Prpf38b 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
228	RIPVPVQKNIDQQIK	acetylation	[1, 2]
408	EKKHKEDKEDRRHRD	acetylation	[3]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [3] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654] 

Functional Description

 May be required for pre-mRNA splicing (Potential). 

Sequence Annotation

 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 36 36 Phosphothreonine.
 MOD_RES 228 228 N6-acetyllysine (By similarity).
 MOD_RES 321 321 Phosphoserine (By similarity).
 MOD_RES 445 445 Phosphoserine (By similarity).
 MOD_RES 470 470 Phosphoserine (By similarity).
 MOD_RES 472 472 Phosphoserine (By similarity).
 MOD_RES 478 478 Phosphoserine (By similarity).
 MOD_RES 523 523 Phosphoserine (By similarity).
 MOD_RES 525 525 Phosphoserine (By similarity).
 MOD_RES 530 530 Phosphoserine (By similarity).  

Keyword

 Acetylation; Coiled coil; Complete proteome; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein; Reference proteome; Spliceosome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 542 AA 

Protein Sequence

Gene Ontology

 GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
 GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
 GO:0008380; P:RNA splicing; IEA:UniProtKB-KW. 

Interpro

 IPR005037; PRP38. 

Pfam

 PF03371; PRP38 

SMART

  

PROSITE

  

PRINTS