UniProt Accession

 BMAL1_HUMAN; O00327; A2I2N6; A8K645; B5ME11; B7WPG7; D3DQW6; O00313; O00314; O00315; O00316; O00317; Q4G136; Q8IUT4; Q99631; Q99649 

Genbank Protein ID

 D89722; AB000812; AB000813; AB000814; AB000815; AB000816; U51627; U60415; AF044288; AK095749; AK291510; EF015894; AC016884; AC022878; CH471064; CH471064; CH471064; CH471064; CH471064; BC016674; BC031214; BC041129 

Genbank Nucleotide ID

 BAA19968.1; BAA19935.1; BAA19936.1; BAA19937.1; BAA19938.1; BAA19939.1; AAC51213.1; AAB37248.1; AAC24353.1; BAG53120.1; BAF84199.1; ABM64205.1; EAW68504.1; EAW68505.1; EAW68510.1; EAW68511.1; EAW68513.1; AAH16674.1; AAH31214.1; AAH41129.2 

Protein Name

 Aryl hydrocarbon receptor nuclear translocator-like protein 1 

Protein Synonyms/Alias

 Basic-helix-loop-helix-PAS protein MOP3; Brain and muscle ARNT-like 1; Class E basic helix-loop-helix protein 5; bHLHe5; Member of PAS protein 3; PAS domain-containing protein 3; bHLH-PAS protein JAP3 

Gene Name

 ARNTL 

Gene Synonyms/Alias

 BHLHE5; BMAL1; MOP3; PASD3 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
138	PYTEANYKPTFLSDD	ubiquitination	[1]
205	PKDIAKVKEQLSSSD	ubiquitination	[1]
259	KCNRPSVKVEDKDFP	sumoylation	[2, 3]
398	QVLQTREKITTNCYK	ubiquitination	[1]
409	NCYKFKIKDGSFITL	ubiquitination	[1]
538	DASSPGGKKILNGGT	acetylation	[4]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Circadian clock control by SUMOylation of BMAL1.
 Cardone L, Hirayama J, Giordano F, Tamaru T, Palvimo JJ, Sassone-Corsi P.
 Science. 2005 Aug 26;309(5739):1390-4. [PMID: 16109848]
 [3] Dual modification of BMAL1 by SUMO2/3 and ubiquitin promotes circadian activation of the CLOCK/BMAL1 complex.
 Lee J, Lee Y, Lee MJ, Park E, Kang SH, Chung CH, Lee KH, Kim K.
 Mol Cell Biol. 2008 Oct;28(19):6056-65. [PMID: 18644859]
 [4] CLOCK-mediated acetylation of BMAL1 controls circadian function.
 Hirayama J, Sahar S, Grimaldi B, Tamaru T, Takamatsu K, Nakahata Y, Sassone-Corsi P.
 Nature. 2007 Dec 13;450(7172):1086-90. [PMID: 18075593] 

Functional Description

 ARNTL-CLOCK heterodimers activate E-box element (5'- CACGTG-3') transcription of a number of proteins of the circadian clock. This transcription is inhibited in a feedback loop by PER, and also by CRY proteins (By similarity). 

Sequence Annotation

 DOMAIN 72 125 bHLH.
 DOMAIN 143 215 PAS 1.
 DOMAIN 326 396 PAS 2.
 DOMAIN 401 444 PAC.
 MOD_RES 538 538 N6-acetyllysine (By similarity).
 CROSSLNK 259 259 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 3D-structure; Acetylation; Activator; Alternative splicing; Biological rhythms; Complete proteome; DNA-binding; Isopeptide bond; Nucleus; Phosphoprotein; Reference proteome; Repeat; Transcription; Transcription regulation; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 626 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:InterPro.
 GO:0016604; C:nuclear body; IEA:Compara.
 GO:0005667; C:transcription factor complex; IPI:MGI.
 GO:0003677; F:DNA binding; IGI:MGI.
 GO:0051879; F:Hsp90 protein binding; IDA:BHF-UCL.
 GO:0000982; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity; ISS:BHF-UCL.
 GO:0001190; F:RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription; IEA:Compara.
 GO:0004871; F:signal transducer activity; IEA:InterPro.
 GO:0032922; P:circadian regulation of gene expression; ISS:UniProtKB.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL.
 GO:0000060; P:protein import into nucleus, translocation; IEA:Compara.
 GO:0042176; P:regulation of protein catabolic process; IEA:Compara. 

Interpro

 IPR011598; bHLH_dom.
 IPR001067; Nuc_translocat.
 IPR001610; PAC.
 IPR000014; PAS.
 IPR013767; PAS_fold.
 IPR013655; PAS_fold_3. 

Pfam

 PF00010; HLH
 PF00989; PAS
 PF08447; PAS_3 

SMART

 SM00353; HLH
 SM00086; PAC
 SM00091; PAS 

PROSITE

 PS50888; BHLH
 PS50113; PAC
 PS50112; PAS 

PRINTS

 PR00785; NCTRNSLOCATR.