CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-006655
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase 
Protein Synonyms/Alias
 NN:DBI PRT; N(1)-alpha-phosphoribosyltransferase 
Gene Name
 cobT 
Gene Synonyms/Alias
 b1991; JW1969 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
214PTDKLANKIDVVRRAacetylation[1]
295PSHLSAEKGARIALSacetylation[1]
Reference
 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 
Functional Description
 Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB). 
Sequence Annotation
 ACT_SITE 318 318 Proton acceptor (By similarity).  
Keyword
 Cobalamin biosynthesis; Complete proteome; Glycosyltransferase; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 359 AA 
Protein Sequence
MQILADLLNT IPAIDSTAMS RAQRHIDGLL KPVGSLGKLE VLAIQLAGMP GLNGIPHVGK 60
KAVLVMCADH GVWEEGVAIS PKEVTAIQAE NMTRGTTGVC VLAEQAGANV HVIDVGIDTA 120
EPIPGLINMR VARGSGNIAS APAMSRRQAE KLLLDVICYT QELAKNGVTL FGVGELGMAN 180
TTPAAAIVST ITGRDPEEVV GIGANLPTDK LANKIDVVRR AITLNQPNPQ DGVDVLAKVG 240
GFDLVGIAGV MLGAASCGLP VLLDGFLSYA AALAACQMSP AIKPYLIPSH LSAEKGARIA 300
LSHLGLEPYL NMEMRLGEGS GAALAMPIIE AACAIYNNMG ELAASNIVLP GNTTSDLNS 359 
Gene Ontology
 GO:0015420; F:cobalamin-transporting ATPase activity; IEA:HAMAP.
 GO:0008939; F:nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity; IGI:EcoCyc.
 GO:0009236; P:cobalamin biosynthetic process; IMP:EcoliWiki.
 GO:0009163; P:nucleoside biosynthetic process; IEA:InterPro. 
Interpro
 IPR003200; Nict_dMeBzImd_PRibTrfase-like.
 IPR023195; Nict_dMeBzImd_PRibTrfase_N.
 IPR017846; Nict_dMeBzImd_PRibTrfase_pro. 
Pfam
 PF02277; DBI_PRT 
SMART
  
PROSITE
  
PRINTS