UniProt Accession

 ADPRH_MOUSE; P54923 

Genbank Protein ID

 L13290; AF244347; BC003437 

Genbank Nucleotide ID

 AAA37259.1; AAF86223.1; AAH03437.1 

Protein Name

 [Protein ADP-ribosylarginine] hydrolase 

Protein Synonyms/Alias

 ADP-ribosylarginine hydrolase; ADP-ribose-L-arginine cleaving enzyme 

Gene Name

 Adprh 

Gene Synonyms/Alias

 Arh1 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
209	EVLPEAKKYITQSGY	acetylation	[1]
209	EVLPEAKKYITQSGY	ubiquitination	[2]
335	VNPANYEKLEYRQRL	acetylation	[1]
335	VNPANYEKLEYRQRL	ubiquitination	[2]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Catalyzes the reverse reaction of mono-ADP-ribosylation. 

Sequence Annotation

  

Keyword

 Complete proteome; Hydrolase; Magnesium; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 362 AA 

Protein Sequence

Gene Ontology

 GO:0003875; F:ADP-ribosylarginine hydrolase activity; IMP:UniProtKB.
 GO:0000287; F:magnesium ion binding; IEA:InterPro.
 GO:0006464; P:cellular protein modification process; IMP:UniProtKB.
 GO:0051725; P:protein de-ADP-ribosylation; IEA:InterPro. 

Interpro

 IPR012108; ADP-ribosylarg_hydro.
 IPR005502; Ribosyl_crysJ1. 

Pfam

 PF03747; ADP_ribosyl_GH 

SMART

  

PROSITE

  

PRINTS