CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037314
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Protein SMG7 
Protein Synonyms/Alias
  
Gene Name
 SMG7 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
759MQQQPLEKKMKPFPMubiquitination[1, 2, 3]
777NHNPSEVKVPEFYWDubiquitination[2]
868MFNEVYGKNLTSSSKubiquitination[1, 2, 3, 4, 5]
1035EQLLMQQKQKQQRGQubiquitination[2]
1037LLMQQKQKQQRGQGTubiquitination[2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [5] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1049 AA 
Protein Sequence
MLVTDLEYAL DKKVEQDLWN HAFKNQITTL QGQAKNRANP NRSEVQANLS LFLEAASGFY 60
TQLLQELCTV FNVDLPCRVK SSQLGIISNK QTHTSAIVKP QSSSCSYICQ HCLVHLGDIA 120
RYRNQTSQAE SYYRHAAQLV PSNGQPYNQL AILASSKGDH LTTIFYYCRS IAVKFPFPAA 180
STNLQKALSK ALESRDEVKT KWGVSDFIKA FIKFHGHVYL SKSLEKLSPL REKLEEQFKR 240
LLFQKAFNSQ QLVHVTVINL FQLHHLRDFS NETEQHTYSQ DEQLCWTQLL ALFMSFLGIL 300
CKCPLQNESQ EESYNAYPLP AVKVSMDWLR LRPRVFQEAV VDERQYIWPW LISLLNSFHP 360
HEEDLSSISA TPLPEEFELQ GFLALRPSFR NLDFSKGHQG ITGDKEGQQR RIRQQRLISI 420
GKWIADNQPR LIQCENEVGK LLFITEIPEL ILEDPSEAKE NLILQETSVI ESLAADGSPG 480
LKSVLSTSRN LSNNCDTGEK PVVTFKENIK TREVNRDQGR SFPPKEVKSQ TELRKTPVSE 540
ARKTPVTQTP TQASNSQFIP IHHPGAFPPL PSRPGFPPPT YVIPPPVAFS MGSGYTFPAG 600
VSVPGTFLQP TAHSPAGNQV QAGKQSHIPY SQQRPSGPGP MNQGPQQSQP PSQQPLTSLP 660
AQPTAQSTSQ LQVQALTQQQ QSPTKAVPAL GKSPPHHSGF QQYQQADASK QLWNPPQVQG 720
PLGKIMPVKQ PYYLQTQDPI KLFEPSLQPP VMQQQPLEKK MKPFPMEPYN HNPSEVKVPE 780
FYWDSSYSMA DNRSVMAQQA NIDRRGKRSP GVFRPEQDPV PRMPFEKSLL EKPSELMSHS 840
SSFLSLTGFS LNQERYPNNS MFNEVYGKNL TSSSKAELSP SMAPQETSLY SLFEGTPWSP 900
SLPASSDHST PASQSPHSSN PSSLPSSPPT HNHNSVPFSN FGPIGTPDNR DRRTADRWKT 960
DKPAMGGFGI DYLSATSSSE SSWHQASTPS GTWTGHGPSM EDSSAVLMES LKSIWSSSMM 1020
HPGPSALEQL LMQQKQKQQR GQGTMNPPH 1049 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0045111; C:intermediate filament cytoskeleton; IDA:HPA. 
Interpro
 IPR018834; DNA/RNA-bd_Est1-type.
 IPR019458; EST1.
 IPR011990; TPR-like_helical. 
Pfam
 PF10374; EST1
 PF10373; EST1_DNA_bind 
SMART
  
PROSITE
  
PRINTS