| Tag | Content |
|---|
| CPLM ID | CPLM-012933 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Polycomb group RING finger protein 3 |
Protein Synonyms/Alias | RING finger protein 3A |
Gene Name | PCGF3 |
Gene Synonyms/Alias | RNF3; RNF3A |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 104 | KQREFYHKLGMEVPG | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. |
Sequence Annotation | ZN_FING 17 56 RING-type. |
Keyword | Alternative splicing; Complete proteome; Metal-binding; Nucleus; Reference proteome; Repressor; Transcription; Transcription regulation; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 242 AA |
Protein Sequence | MEFPKMLTRK IKLWDINAHI TCRLCSGYLI DATTVTECLH TFCRSCLVKY LEENNTCPTC 60
RIVIHQSHPL QYIGHDRTMQ DIVYKLVPGL QEAEMRKQRE FYHKLGMEVP GDIKGETCSA 120
KQHLDSHRNG ETKADDSSNK EAAEEKPEED NDYHRSDEQV SICLECNSSK LRGLKRKWIR 180
CSAQATVLHL KKFIAKKLNL SSFNELDILC NEEILGKDHT LKFVVVTRWR FKKAPLLLHY 240
RPKMDLL 247 |
Gene Ontology | GO:0031519; C:PcG protein complex; IDA:UniProtKB. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |