CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037303
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Histone-binding protein RBBP7 
Protein Synonyms/Alias
  
Gene Name
 RBBP7 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
4****MASKEMFEDTVacetylation[1, 2]
4****MASKEMFEDTVubiquitination[2, 3, 4]
110GKIECEIKINHEGEVacetylation[1, 2, 5]
110GKIECEIKINHEGEVubiquitination[2, 4, 6]
133NPHIIATKTPSSDVLubiquitination[6, 7, 8]
146VLVFDYTKHPAKPDPubiquitination[2, 4, 6]
150DYTKHPAKPDPSGECacetylation[2]
150DYTKHPAKPDPSGECmethylation[9]
150DYTKHPAKPDPSGECubiquitination[2, 4, 6]
168LRLRGHQKEGYGLSWubiquitination[6]
254TRSNTTSKPSHLVDAubiquitination[2, 4, 6]
307LHTFESHKDEIFQVHubiquitination[6, 7]
339LNVWDLSKIGEEQSAubiquitination[4, 6, 8]
Reference
 [1] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [5] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [6] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [7] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [8] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [9] Large-scale global identification of protein lysine methylation in vivo.
 Cao XJ, Arnaudo AM, Garcia BA.
 Epigenetics. 2013 May 1;8(5):477-85. [PMID: 23644510
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Nucleus; Reference proteome; Repeat; WD repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 416 AA 
Protein Sequence
MASKEMFEDT VEERVINEEY KIWKKNTPFL YDLVMTHALQ WPSLTVQWLP EVTKPEGKDY 60
ALHWLVLGTH TSDEQNHLVV ARVHIPNDDA QFDASHCDSD KGGKIECEIK INHEGEVNRA 120
RYMPQNPHII ATKTPSSDVL VFDYTKHPAK PDPSGECNPD LRLRGHQKEG YGLSWNSNLS 180
GHLLSASDDH TVCLWDINAG PKEGKIVDAK AIFTGHSAVV EDVAWHLLHE SLFGSVADDQ 240
KLMIWDTRSN TTSKPSHLVD AHTAEVNCLS FNPYSEFILA TGSADKTVAL WDLRNLKLKL 300
HTFESHKDEI FQVHWSPHNE TILASSGTDR RLNVWDLSKI GEEQSAEDAE DGPPELLFIH 360
GGHTAKISDF SWNPNEPWVI CSVSEDNIMQ IWQMAENIYN DEESDVTTSE LEGQGS 416 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-KW. 
Interpro
 IPR020472; G-protein_beta_WD-40_rep.
 IPR022052; Histone-bd_RBBP4.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR019775; WD40_repeat_CS.
 IPR017986; WD40_repeat_dom. 
Pfam
 PF12265; CAF1C_H4-bd
 PF00400; WD40 
SMART
 SM00320; WD40 
PROSITE
 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 
PRINTS
 PR00320; GPROTEINBRPT.