CPLM-036563

CPLM 1.0 - Compendium of Protein Lysine Modification

Tag

Content

CPLM ID

CPLM-036563

UniProt Accession

Genbank Protein ID

HQ205186; HQ205187; HQ205188; HQ205189; HQ205190; HQ205191; HQ205192; HQ205193; HQ205194; HQ205195; HQ205196; HQ205197; HQ205198; HQ205199; HQ205200; HQ205201; HQ205202; HQ205204; HQ205205; HQ205206; HQ205207; HQ205208; HQ205209; HQ205210; HQ205211; HQ205212; HQ205213; HQ205214; HQ205215; HQ205216; HQ205217; HQ205218; HQ205219; HQ205221; HQ205222; HQ205223; HQ205224; HQ205225; CH471154

Genbank Nucleotide ID

ADP90654.1; ADP90655.1; ADP90656.1; ADP90657.1; ADP90658.1; ADP90659.1; ADP90660.1; ADP90661.1; ADP90662.1; ADP90663.1; ADP90664.1; ADP90665.1; ADP90666.1; ADP90667.1; ADP90668.1; ADP90669.1; ADP90670.1; ADP90672.1; ADP90673.1; ADP90674.1; ADP90675.1; ADP90676.1; ADP90677.1; ADP90678.1; ADP90679.1; ADP90680.1; ADP90681.1; ADP90682.1; ADP90683.1; ADP90684.1; ADP90685.1; ADP90686.1; ADP90687.1; ADP90689.1; ADP90690.1; ADP90691.1; ADP90692.1; ADP90693.1; EAW93209.1

Protein Name

APEX nuclease (Apurinic/apyrimidinic endonuclease) 2, isoform CRA_b

Protein Synonyms/Alias

DNA-apurinic or apyrimidinic site lyase 2

Gene Name

APEX2

Gene Synonyms/Alias

hCG_18950

Created Date

July 27, 2013

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Lysine Modification

Position	Peptide	Type	References
338	EFAGTQLKILRFLVP	ubiquitination	[1, 2]
371	RVQTCQNKAQVRSTR	ubiquitination	[1]
457	ELRTSFWKSVLAGPL	ubiquitination	[1, 2]

Reference

[1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
[2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
Chen Z, Zhou Y, Song J, Zhang Z.
Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]

Functional Description

Sequence Annotation

Keyword

Endonuclease; Hydrolase; Lyase; Nuclease.

Sequence Source

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

Protein Length

518 AA

Protein Sequence

MLRVVSWNIN GIRRPLQGVA NQEPSNCAAV AVGRILDELD ADIVCLQETK VTRDALTEPL 60
AIVEGYNSYF SFSRNRSGYS GVATFCKDNA TPVAAEEGLS GLFATQNGDV GCYGNMDEFT 120
QEELRALDSE GRALLTQHKI RTWEGKEKTL TLINVYCPHA DPGRPERLVF KMRFYRLLQI 180
RAEALLAAGS HVIILGDLNT AHRPIDHWDA VNLECFEEDP GRKWMDSLLS NLGCQSASHV 240
GPFIDSYRCF QPKQEGAFTC WSAVTGARHL NYGSRLDYVL GDRTLVIDTF QASFLLPEVM 300
GSDHCPVGAV LSVSSVPAKQ CPPLCTRFLP EFAGTQLKIL RFLVPLEQSP VLEQSTLQHN 360
NQTRVQTCQN KAQVRSTRPQ PSQVGSSRGQ KNLKSYFQPS PSCPQASPDI ELPSLPLMSA 420
LMTPKTPEEK AVAKVVKGQA KTSEAKDEKE LRTSFWKSVL AGPLRTPLCG GHREPCVMRT 480
VKKPGPNLGR RFYMCARPRG PPTDPSSRCN FFLWSRPS 518

Gene Ontology

GO:0005743; C:mitochondrial inner membrane; IEA:Compara.
GO:0005634; C:nucleus; IEA:Compara.
GO:0003677; F:DNA binding; IEA:InterPro.
GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006281; P:DNA repair; IEA:InterPro.
GO:0090305; P:nucleic acid phosphodiester bond hydrolysis; IEA:GOC.

Interpro

IPR020847; AP_endonuclease_F1_BS.
IPR005135; Endo/exonuclease/phosphatase.
IPR004808; ExoDNase_III.
IPR010666; Znf_GRF.

Pfam

PF03372; Exo_endo_phos
PF06839; zf-GRF

SMART

PROSITE

PS00726; AP_NUCLEASE_F1_1
PS51435; AP_NUCLEASE_F1_4

PRINTS