UniProt Accession

 TTHY_MOUSE; P07309 

Genbank Protein ID

 X03351; D00073; D89076; AK018701; BC024702 

Genbank Nucleotide ID

 CAA27057.1; BAA00050.1; BAA13757.1; BAB31352.1; AAH24702.1 

Protein Name

 Transthyretin 

Protein Synonyms/Alias

 Prealbumin 

Gene Name

 Ttr 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
35	SKCPLMVKVLDAVRG	acetylation	[1, 2]
35	SKCPLMVKVLDAVRG	ubiquitination	[3]
55	VAVKVFKKTSEGSWE	ubiquitination	[3]
68	WEPFASGKTAESGEL	ubiquitination	[3]
83	HGLTTDEKFVEGVYR	ubiquitination	[3]
96	YRVELDTKSYWKTLG	ubiquitination	[3]

Reference

 [1] The fasted/fed mouse metabolic acetylome: N6-acetylation differences suggest acetylation coordinates organ-specific fuel switching.
 Yang L, Vaitheesvaran B, Hartil K, Robinson AJ, Hoopmann MR, Eng JK, Kurland IJ, Bruce JE.
 J Proteome Res. 2011 Sep 2;10(9):4134-49. [PMID: 21728379]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [3] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. 

Sequence Annotation

 REGION 135 139 Thyroid hormone binding (By similarity).
 BINDING 35 35 Thyroid hormone (By similarity).
 BINDING 74 74 Thyroid hormone (By similarity).
 MOD_RES 62 62 4-carboxyglutamate (By similarity).
 CARBOHYD 118 118 N-linked (GlcNAc...).  

Keyword

 3D-structure; Complete proteome; Gamma-carboxyglutamic acid; Glycoprotein; Hormone; Reference proteome; Secreted; Signal; Thyroid hormone; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 147 AA 

Protein Sequence

Gene Ontology

 GO:0005615; C:extracellular space; IEA:Compara.
 GO:0043234; C:protein complex; IEA:Compara.
 GO:0042562; F:hormone binding; IEA:Compara.
 GO:0042572; P:retinol metabolic process; IEA:Compara.
 GO:0006810; P:transport; IEA:UniProtKB-KW. 

Interpro

 IPR023418; Thyroxine_BS.
 IPR000895; Transthyretin/HIU_hydrolase.
 IPR023416; Transthyretin/HIU_hydrolase_SF.
 IPR023419; Transthyretin_CS. 

Pfam

 PF00576; Transthyretin 

SMART

 SM00095; TR_THY 

PROSITE

 PS00768; TRANSTHYRETIN_1
 PS00769; TRANSTHYRETIN_2 

PRINTS

 PR00189; TRNSTHYRETIN.