CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-020293
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Caspase recruitment domain-containing protein 10 
Protein Synonyms/Alias
 CARD-containing MAGUK protein 3; Carma 3 
Gene Name
 CARD10 
Gene Synonyms/Alias
 CARMA3 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
616GGPEPQDKGPDGLSFubiquitination[1]
727DPHALCVKAQEILRLubiquitination[2]
778QLLEVQEKCLPSSRHubiquitination[3, 4]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
 Activates NF-kappa-B via BCL10 and IKK. 
Sequence Annotation
 DOMAIN 23 115 CARD.  
Keyword
 Coiled coil; Complete proteome; Cytoplasm; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1032 AA 
Protein Sequence
MPGRAEAGEA EEEAGAGSGS EAEEDALWER IEGVRHRLAR ALNPAKLTPY LRQCRVIDEQ 60
DEEEVLSTYR FPCRVNRTGR LMDILRCRGK RGYEAFLEAL EFYYPEHFTL LTGQEPAQRC 120
SMILDEEGPE GLTQFLMTEV RRLREARKSQ LQREQQLQAR GRVLEEERAG LEQRLRDQQQ 180
AQERCQRLRE DWEAGSLELL RLKDENYMIA MRLAQLSEEK NSAVLRSRDL QLAVDQLKLK 240
VSRLEEECAL LRRARGPPPG AEEKEKEKEK EKEPDNVDLV SELRAENQRL TASLRELQEG 300
LQQEASRPGA PGSERILLDI LEHDWREAQD SRQELCQKLH AVQGELQWAE ELRDQYLQEM 360
EDLRLKHRTL QKDCDLYKHR MATVLAQLEE IEKERDQAIQ SRDRIQLQYS QSLIEKDQYR 420
KQVRGLEAER DELLTTLTSL EGTKALLEVQ LQRAQGGTCL KACASSHSLC SNLSSTWSLS 480
EFPSPLGGPE ATGEAAVMGG PEPHNSEEAT DSEKEINRLS ILPFPPSAGS ILRRQREEDP 540
APPKRSFSSM SDITGSVTLK PWSPGLSSSS SSDSVWPLGK PEGLLARGCG LDFLNRSLAI 600
RVSGRSPPGG PEPQDKGPDG LSFYGDRWSG AVVRRVLSGP GSARMEPREQ RVEAAGLEGA 660
CLEAEAQQRT LLWNQGSTLP SLMDSKACQS FHEALEAWAK GPGAEPFYIR ANLTLPERAD 720
PHALCVKAQE ILRLVDSAYK RRQEWFCTRV DPLTLRDLDR GTVPNYQRAQ QLLEVQEKCL 780
PSSRHRGPRS NLKKRALDQL RLVRPKPVGA PAGDSPDQLL LEPCAEPERS LRPYSLVRPL 840
LVSALRPVVL LPECLAPRLI RNLLDLPSSR LDFQVCPAES LSGEELCPSS APGAPKAQPA 900
TPGLGSRIRA IQESVGKKHC LLELGARGVR ELVQNEIYPI VIHVEVTEKN VREVRGLLGR 960
PGWRDSELLR QCRGSEQVLW GLPCSWVQVP AHEWGHAEEL AKVVRGRILQ EQARLVWVEC 1020
GSSRGCPSSS EA 1032 
Gene Ontology
 GO:0032449; C:CBM complex; NAS:UniProtKB.
 GO:0030159; F:receptor signaling complex scaffold activity; NAS:UniProtKB.
 GO:0007250; P:activation of NF-kappaB-inducing kinase activity; IDA:UniProtKB.
 GO:0006461; P:protein complex assembly; NAS:UniProtKB.
 GO:0042981; P:regulation of apoptotic process; IEA:InterPro. 
Interpro
 IPR001315; CARD.
 IPR011029; DEATH-like_dom. 
Pfam
 PF00619; CARD 
SMART
  
PROSITE
 PS50209; CARD 
PRINTS