CPLM-017753

CPLM 1.0 - Compendium of Protein Lysine Modification

Tag

Content

CPLM ID

CPLM-017753

UniProt Accession

INADL_HUMAN; Q8NI35; O15249; O43742; O60833; Q5VUA5; Q5VUA6; Q5VUA7; Q5VUA8; Q5VUA9; Q5VUB0; Q8WU78; Q9H3N9

Genbank Protein ID

AJ001306; AJ224747; AJ224748; AB044807; AF397170; AL590374; AL136458; AL353802; AL590374; AC097064; AL136458; AL353802; AL449143; AL590374; AC097064; AL136458; AL353802; AL449143; AL353802; AL136458; AL590374; AL353802; AC097064; AL136458; AL449143; AL590374; AL353802; AC097064; AL136458; AL449143; AL590374; AL449143; AC097064; AL136458; AL353802; AL590374; AL449143; AC097064; AL136458; AL353802; AL590374; AL136458; AL353802; AL590374; AL136458; AC097064; AL353802; AL449143; AL590374; AL136458; AC097064; AL353802; AL449143; AL590374; BC021135

Genbank Nucleotide ID

CAA04666.1; CAA12112.1; CAA12113.1; BAB19683.1; AAM28433.1; CAH70416.1; CAH70416.1; CAH70416.1; CAH70418.1; CAH70418.1; CAH70418.1; CAH70418.1; CAH70418.1; CAH70420.1; CAH70420.1; CAH70420.1; CAH70420.1; CAH70420.1; CAI22258.1; CAI22258.1; CAI22258.1; CAI22260.1; CAI22260.1; CAI22260.1; CAI22260.1; CAI22260.1; CAI22262.1; CAI22262.1; CAI22262.1; CAI22262.1; CAI22262.1; CAI15923.1; CAI15923.1; CAI15923.1; CAI15923.1; CAI15923.1; CAI15925.1; CAI15925.1; CAI15925.1; CAI15925.1; CAI15925.1; CAI21733.1; CAI21733.1; CAI21733.1; CAI21734.1; CAI21734.1; CAI21734.1; CAI21734.1; CAI21734.1; CAI21737.1; CAI21737.1; CAI21737.1; CAI21737.1; CAI21737.1; AAH21135.1

Protein Name

InaD-like protein

Protein Synonyms/Alias

Inadl protein; hINADL; Pals1-associated tight junction protein; Protein associated to tight junctions

Gene Name

INADL

Gene Synonyms/Alias

PATJ

Created Date

July 27, 2013

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Lysine Modification

Position	Peptide	Type	References
822	FRDEPYFKEELVDEP	ubiquitination	[1]
1225	EDAFTDQKIRQRYAD	ubiquitination	[1]

Reference

[1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]

Functional Description

Scaffolding protein that may bring different proteins into adjacent positions at the cell membrane. May regulate protein targeting, cell polarity and integrity of tight junctions. May regulate the surface expression and/or function of ASIC3 in sensory neurons.

Sequence Annotation

DOMAIN 1 65 L27.
DOMAIN 134 221 PDZ 1.
DOMAIN 248 328 PDZ 2.
DOMAIN 365 453 PDZ 3.
DOMAIN 553 639 PDZ 4.
DOMAIN 686 772 PDZ 5.
DOMAIN 1068 1160 PDZ 6.
DOMAIN 1239 1322 PDZ 7.
DOMAIN 1437 1520 PDZ 8.
DOMAIN 1533 1615 PDZ 9.
DOMAIN 1676 1762 PDZ 10.
MOD_RES 455 455 Phosphoserine (By similarity).
MOD_RES 522 522 Phosphoserine.
MOD_RES 645 645 Phosphoserine.
MOD_RES 1209 1209 Phosphothreonine.
MOD_RES 1212 1212 Phosphoserine.
MOD_RES 1508 1508 Phosphothreonine.

Keyword

3D-structure; Alternative splicing; Cell junction; Cell membrane; Complete proteome; Cytoplasm; Membrane; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Tight junction.

Sequence Source

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

Protein Length

1801 AA

Protein Sequence

MPENPATDKL QVLQVLDRLK MKLQEKGDTS QNEKLSMFYE TLKSPLFNQI LTLQQSIKQL 60
KGQLNHIPSD CSANFDFSRK GLLVFTDGSI TNGNVHRPSN NSTVSGLFPW TPKLGNEDFN 120
SVIQQMAQGR QIEYIDIERP STGGLGFSVV ALRSQNLGKV DIFVKDVQPG SVADRDQRLK 180
ENDQILAINH TPLDQNISHQ QAIALLQQTT GSLRLIVARE PVHTKSSTSS SLNDTTLPET 240
VCWGHVEEVE LINDGSGLGF GIVGGKTSGV VVRTIVPGGL ADRDGRLQTG DHILKIGGTN 300
VQGMTSEQVA QVLRNCGNSV RMLVARDPAG DISVTPPAPA ALPVALPTVA SKGPGSDSSL 360
FETYNVELVR KDGQSLGIRI VGYVGTSHTG EASGIYVKSI IPGSAAYHNG HIQVNDKIVA 420
VDGVNIQGFA NHDVVEVLRN AGQVVHLTLV RRKTSSSTSP LEPPSDRGTV VEPLKPPALF 480
LTGAVETETN VDGEDEEIKE RIDTLKNDNI QALEKLEKVP DSPENELKSR WENLLGPDYE 540
VMVATLDTQI ADDAELQKYS KLLPIHTLRL GVEVDSFDGH HYISSIVSGG PVDTLGLLQP 600
EDELLEVNGM QLYGKSRREA VSFLKEVPPP FTLVCCRRLF DDEASVDEPR RTETSLPETE 660
VDHNMDVNTE EDDDGELALW SPEVKIVELV KDCKGLGFSI LDYQDPLDPT RSVIVIRSLV 720
ADGVAERSGG LLPGDRLVSV NEYCLDNTSL AEAVEILKAV PPGLVHLGIC KPLVEDNEEE 780
SCYILHSSSN EDKTEFSGTI HDINSSLILE APKGFRDEPY FKEELVDEPF LDLGKSFHSQ 840
QKEIEQSKEA WEMHEFLTPR LQEMDEEREI LVDEEYELYQ DPSPSMELYP LSHIQEATPV 900
PSVNELHFGT QWLHDNEPSE SQEARTGRTV YSQEAQPYGY CPENVMKENF VMESLPSVPS 960
TEGNSQQGRF DDLENLNSLA KTSLDLGMIP NDVQGPSLLI DLPVVAQRRE QEDLPLYQHQ 1020
ATRVISKASA YTGMLSSRYA TDTCELPERE EGEGEETPNF SHWGPPRIVE IFREPNVSLG 1080
ISIVGGQTVI KRLKNGEELK GIFIKQVLED SPAGKTNALK TGDKILEVSG VDLQNASHSE 1140
AVEAIKNAGN PVVFIVQSLS STPRVIPNVH NKANKITGNQ NQDTQEKKEK RQGTAPPPMK 1200
LPPPYKALTD DSDENEEEDA FTDQKIRQRY ADLPGELHII ELEKDKNGLG LSLAGNKDRS 1260
RMSIFVVGIN PEGPAAADGR MRIGDELLEI NNQILYGRSH QNASAIIKTA PSKVKLVFIR 1320
NEDAVNQMAV TPFPVPSSSP SSIEDQSGTE PISSEEDGSV EVGIKQLPES ESFKLAVSQM 1380
KQQKYPTKVS FSSQEIPLAP ASSYHSTDAD FTGYGGFQAP LSVDPATCPI VPGQEMIIEI 1440
SKGRSGLGLS IVGGKDTPLF WRLGSPRAWS QHLVRAFMLH HPVTEVEGQN AIVIHEVYEE 1500
GAAARDGRLW AGDQILEVNG VDLRNSSHEE AITALRQTPQ KVRLVVYRDE AHYRDEENLE 1560
IFPVDLQKKA GRGLGLSIVG KR 1582

Gene Ontology

GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell.
GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
GO:0005886; C:plasma membrane; TAS:Reactome.
GO:0005923; C:tight junction; IDA:MGI.
GO:0035556; P:intracellular signal transduction; NAS:UniProtKB.
GO:0070830; P:tight junction assembly; TAS:Reactome.

Interpro

IPR004172; L27.
IPR015132; L27_2.
IPR001478; PDZ.

Pfam

PF09045; L27_2
PF00595; PDZ

SMART

SM00569; L27
SM00228; PDZ

PROSITE

PS51022; L27
PS50106; PDZ

PRINTS