CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-043804
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 THUMP domain-containing protein 3 
Protein Synonyms/Alias
  
Gene Name
 THUMPD3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
94TCNRAGEKHCFTSNEubiquitination[1, 2]
115GAVQDYFKWKADMTNubiquitination[1]
226NIASLLTKSQIKEG*ubiquitination[1, 2, 3, 4]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 232 AA 
Protein Sequence
XKRKKINQNS SKEKINNGQE VKIDQRNVKK EFTSHALDSH ILDYYENPAI KEDVSTLIGD 60
DLASCKDETD ESSKEETEPQ VLKFRVTCNR AGEKHCFTSN EAARDFGGAV QDYFKWKADM 120
TNFDVEVLLN IHDNEVIVGI ALTEESLHRR NITHFGPTTL RSTLAYGMLR LCDPLPYDII 180
VDPMCGTGAI PIEGATEWSD CFHIAGDNNP LAVNRAANNI ASLLTKSQIK EG 232 
Gene Ontology
 GO:0003723; F:RNA binding; IEA:InterPro. 
Interpro
 IPR000241; RNA_methylase_dom.
 IPR004114; THUMP. 
Pfam
 PF02926; THUMP
 PF01170; UPF0020 
SMART
 SM00981; THUMP 
PROSITE
 PS51165; THUMP
 PS01261; UPF0020 
PRINTS