CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017285
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Alpha/beta hydrolase domain-containing protein 11 
Protein Synonyms/Alias
 Abhydrolase domain-containing protein 11; Williams-Beuren syndrome chromosomal region 21 protein homolog 
Gene Name
 Abhd11 
Gene Synonyms/Alias
 Wbscr21 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
79TNFNSLAKAMVQRTGacetylation[1]
79TNFNSLAKAMVQRTGsuccinylation[1]
184KAVEIPEKVPHSQARacetylation[2]
196QARKLADKQLSSVVKacetylation[2]
Reference
 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [2] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123
Functional Description
  
Sequence Annotation
 ACT_SITE 133 133 Charge relay system (By similarity).
 ACT_SITE 229 229 Charge relay system (By similarity).
 ACT_SITE 288 288 Charge relay system (By similarity).  
Keyword
 Complete proteome; Hydrolase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 307 AA 
Protein Sequence
MLRWARAWRV PRGVLGASSP RRLAVPVTFC SSRSSGQENA DLRPLPLSYN LLDGDATLPA 60
IVFLHGLFGS KTNFNSLAKA MVQRTGRRVL TVDARNHGDS PHSPDASYEA MSQDLQGLLP 120
QLGLVPCVLV GHSMGGKTAM LLALQRPDVV ERLVVVDISP VGTTPGSHIG AFIAAMKAVE 180
IPEKVPHSQA RKLADKQLSS VVKEAGIRQF LLTNLVEVGG RFSWRLNLDT LAQHLDKIMT 240
FPQQREPYSG PTLFLLGGNS TYVQPSHHSE IRRLFPQAQI QTVPNAGHWV HSDKPQDFMD 300
AVTSFLA 307 
Gene Ontology
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
 GO:0008152; P:metabolic process; IEA:GOC. 
Interpro
 IPR000073; AB_hydrolase_1.
 IPR000639; Epox_hydrolase-like. 
Pfam
  
SMART
  
PROSITE
  
PRINTS
 PR00111; ABHYDROLASE.
 PR00412; EPOXHYDRLASE.