CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-030992
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 cDNA FLJ60299, highly similar to Rab GDP dissociation inhibitor beta 
Protein Synonyms/Alias
  
Gene Name
  
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
58TPLEDLYKRFKIPGSubiquitination[1, 2]
61EDLYKRFKIPGSPPEubiquitination[3]
116TEGSFVYKGGKIYKVubiquitination[1]
146FEKRRFRKFLVYVANubiquitination[2, 3]
157YVANFDEKDPRTFEGubiquitination[1]
168TFEGIDPKKTTMRDVubiquitination[1]
178TMRDVYKKFDLGQDVubiquitination[3]
214YETINRIKLYSESLAubiquitination[1, 3, 4]
225ESLARYGKSPYLYPLubiquitination[1, 2, 3, 4]
257GGTYMLNKPIEEIIVubiquitination[1]
273NGKVIGVKSEGEIARubiquitination[1, 4]
364VSTTVETKEPEKEIRubiquitination[1]
422ETTCDDIKNIYKRMTubiquitination[2, 4]
426DDIKNIYKRMTGSEFubiquitination[4]
439EFDFEEMKRKKNDIYubiquitination[1, 4]
442FEEMKRKKNDIYGEDubiquitination[4]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [3] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [4] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 
Functional Description
  
Sequence Annotation
  
Keyword
  
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 449 AA 
Protein Sequence
MSLGKRKPSS FYLANFLGKE CILSGIMSVN GKKVLHMDRN PYYGGESASI TPLEDLYKRF 60
KIPGSPPESM GRGRDWNVDL IPKFLMANGQ LVKMLLYTEV TRYLDFKVTE GSFVYKGGKI 120
YKVPSTEAEA LASSLMGLFE KRRFRKFLVY VANFDEKDPR TFEGIDPKKT TMRDVYKKFD 180
LGQDVIDFTG HALALYRTDD YLDQPCYETI NRIKLYSESL ARYGKSPYLY PLYGLGELPQ 240
GFARLSAIYG GTYMLNKPIE EIIVQNGKVI GVKSEGEIAR CKQLICDPSY VKDRVEKVGQ 300
VIRVICILSH PIKNTNDANS CQIIIPQNQV NRKSDIYVCM ISFAHNVAAQ GKYIAIVSTT 360
VETKEPEKEI RPALELLEPI EQKFVSISDL LVPKDLGTES QIFISRTYDA TTHFETTCDD 420
IKNIYKRMTG SEFDFEEMKR KKNDIYGED 449 
Gene Ontology
 GO:0005093; F:Rab GDP-dissociation inhibitor activity; IEA:InterPro.
 GO:0015031; P:protein transport; IEA:InterPro. 
Interpro
 IPR018203; GDP_dissociation_inhibitor.
 IPR000806; RabGDI. 
Pfam
 PF00996; GDI 
SMART
  
PROSITE
  
PRINTS
 PR00892; RABGDI.
 PR00891; RABGDIREP.