| Tag | Content |
|---|
| CPLM ID | CPLM-009983 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Leucine-rich repeat-containing protein 7 |
Protein Synonyms/Alias | Densin-180; Densin; Protein LAP1 |
Gene Name | Lrrc7 |
Gene Synonyms/Alias | Lap1 |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 418 | TEAHPETKQRVLTNY | ubiquitination | [1] | | 610 | ANTEQTVKEKFEHKW | ubiquitination | [1] |
|
Reference | [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J. J Proteome Res. 2012 Sep 7;11(9):4722-32. [ PMID: 22871113] |
Functional Description | Required for normal synaptic spine architecture and function. Necessary for DISC1 and GRM5 localization to postsynaptic density complexes and for both N-methyl D-aspartate receptor-dependent and metabotropic glutamate receptor-dependent long term depression (By similarity). |
Sequence Annotation | REPEAT 23 44 LRR 1.
REPEAT 47 68 LRR 2.
REPEAT 70 91 LRR 3.
REPEAT 93 114 LRR 4.
REPEAT 116 137 LRR 5.
REPEAT 139 161 LRR 6.
REPEAT 162 183 LRR 7.
REPEAT 185 206 LRR 8.
REPEAT 208 229 LRR 9.
REPEAT 231 253 LRR 10.
REPEAT 254 275 LRR 11.
REPEAT 277 298 LRR 12.
REPEAT 300 321 LRR 13.
REPEAT 323 344 LRR 14.
REPEAT 346 367 LRR 15.
REPEAT 369 391 LRR 16.
REPEAT 392 413 LRR 17.
DOMAIN 1398 1488 PDZ.
MOD_RES 90 90 Phosphoserine (Probable).
MOD_RES 197 197 Phosphoserine (Probable).
MOD_RES 850 850 Phosphoserine (By similarity).
MOD_RES 865 865 Phosphothreonine (By similarity).
MOD_RES 933 933 Phosphoserine (By similarity).
MOD_RES 949 949 Phosphoserine (By similarity).
MOD_RES 1392 1392 Phosphoserine (By similarity). |
Keyword | Alternative splicing; Cell junction; Cell membrane; Complete proteome; Cytoplasm; Direct protein sequencing; Glycoprotein; Leucine-rich repeat; Membrane; Phosphoprotein; Postsynaptic cell membrane; Reference proteome; Repeat; Synapse. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1490 AA |
Protein Sequence | MTTKRKLIGR LVPCRCFRGE EEIISVLDYS HCSLQQVPKE VFNFERTLEE LYLDANQIEE 60
LPKQLFNCQA LRKLSIPDND LSSLPTSIAS LVNLKELDIS KNGVQEFPEN IKCCKCLTII 120
EASVNPISKL PDGFTQLLNL TQLYLNDAFL EFLPANFGRL VKLRILELRE NHLKTLPKSM 180
HKLAQLERLD LGNNEFSELP EVLDQIQNLR ELWMDNNALQ VLPGSIGKLK MLVYLDMSKN 240
RIETVDMDIS GCEALEDLLL SSNMLQQLPD SIGLLKKLTT LKVDDNQLTM LPNTIGNLSL 300
LEEFDCSCNE LESLPPTIGY LHSLRTLAVD ENFLPELPRE IGSCKNVTVM SLRSNKLEFL 360
PEEIGQMQRL RVLNLSDNRL KNLPFSFTKL KELAALWLSD NQSKALIPLQ TEAHPETKQR 420
VLTNYMFPQQ PRGDEDFQSD SDSFNPTLWE EQRQQRMTVA FEFEDKKEDD ESAGKVKALS 480
CQAPWDRGQR GITLQPARLS GDCCTPWARC DQQIQDMPVP QSDPQLAWGC ISGLQQERSM 540
CAPLPVAAQS TTLPSLSGRQ VEINLKRYPT PYPEDLKNMV KSVQNLVGKP SHGVRVENAN 600
PTANTEQTVK EKFEHKWPVA PKEITVEDSF VHPANEMRIG ELHPSLAETP LYPPKLVLLG 660
KDKKESTDES EVDKTHCLNN SVSSGTYSDY SPSQASSASS NTRVKVGSLQ PTTKDAVHNS 720
LWGNRIAPPF PQPLDAKPLL TQREAVPPGN LPQRPDRLPM SDAFPDNWTD GSHYDNTGFV 780
SEEATGENAN NNPLLSSKAR SVPAHGRRPL IRQERIVGVP LELEQSTHRH TPETEVPPSN 840
PWQNWTRTPS PFEDRTAFPS KLETTPTTSP LPERKDHMKE PTETPGPFSP GVPWEYHDPT 900
PNRSLGNVFS QIHCRPDSSK GVIAISKSTE RLSPLMKDIK SNKFKKSQSI DEIDVGTYKV 960
YNIPLENYAS GSDHLGSHER PDKFLGPEHG MSSMSRSQSV PMLDDEMLMY GSSKGPPQQK 1020
ASMTKKVYQF DQSFNPQGAV EVKAEKRIPP PFAHNSEYVQ QPGKNIAKDL VSPRAYRGYP 1080
PMEQMFSFSQ PSVNEDAMVN AQFASQGPRA GFLRRADSLA SSTEMAMFRR VSEPHELPPG 1140
DRYGRAAYRG GLEGQSSVSM TDPQFLKRNG RYEDEHPSYQ EVKAQAGSFP AKNLTQRRPL 1200
SARSYSTESY GASQTRPVSA RPTMAALLEK IPSDYNLGNY GDKTSDNSDI KTRPTPVKGE 1260
ESCGKMPADW RQQLLRHIEA RRLDRTPSQQ SNILDNGQED VSPSGQWNPY PLGRRDVPPD 1320
TITKKAGSHI QTLMGSQSLQ HRSREQQPYE GNINKVTIQQ FQSPLPIQIP SSQATRGPQP 1380
GRCLIQTKGQ RSMDGYPEQF CVRIEKNPGL GFSISGGISG QGNPFKPSDK GIFVTRVQPD 1440
GPASNLLQPG DKILQANGHS FVHMEHEKAV LLLKSFQNTV DLVIQRELTV 1490 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |