CPLM-002597

Genbank Nucleotide ID

Low affinity immunoglobulin gamma Fc region receptor II

Protein Synonyms/Alias

Fc gamma receptor IIB; Fc-gamma RII; Fc-gamma-RIIB; FcRII; IgG Fc receptor II beta; Lymphocyte antigen 17; Ly-17; CD32

Mus musculus (Mouse)

Position	Peptide	Type	References
239	SLVYLKKKQVPDNPP	ubiquitination	[1]
266	TITYSLLKHPEALDE	ubiquitination	[1]

[1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]

Functional Description

Receptor for the Fc region of complexed immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of antigen-antibody complexes from the circulation and modulation of antibody production by B-cells. Isoform IIB1 and isoform IIB1' form caps but fail to mediate endocytosis or phagocytosis. Isoform IIB2 can mediate the endocytosis of soluble immune complexes via clathrin- coated pits. Isoform IIB1 and isoform IIB2 can down-regulate B- cell, T-cell, and mast cell activation when coaggregated to B-cell receptors for AG (BCR), T-cell receptors for AG (TCR), and Fc receptors, respectively.

DOMAIN 50 106 Ig-like C2-type 1.
DOMAIN 131 189 Ig-like C2-type 2.
MOTIF 307 312 ITIM motif.
MOD_RES 309 309 Phosphotyrosine; by SRC-type Tyr-kinases
MOD_RES 326 326 Phosphotyrosine.
CARBOHYD 65 65 N-linked (GlcNAc...) (Potential).
CARBOHYD 92 92 N-linked (GlcNAc...) (Potential).
CARBOHYD 166 166 N-linked (GlcNAc...) (Potential).
CARBOHYD 173 173 N-linked (GlcNAc...) (Potential).
DISULFID 57 99 By similarity.
DISULFID 138 182 By similarity.

Alternative splicing; Cell membrane; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Disulfide bond; Glycoprotein; IgG-binding protein; Immunoglobulin domain; Membrane; Phosphoprotein; Polymorphism; Receptor; Reference proteome; Repeat; Secreted; Signal; Transmembrane; Transmembrane helix.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
GO:0009897; C:external side of plasma membrane; IDA:MGI.
GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO:0005887; C:integral to plasma membrane; IC:MGI.
GO:0019864; F:IgG binding; IDA:MGI.
GO:0005057; F:receptor signaling protein activity; TAS:MGI.
GO:0019886; P:antigen processing and presentation of exogenous peptide antigen via MHC class II; IMP:MGI.
GO:0007166; P:cell surface receptor signaling pathway; IMP:MGI.
GO:0071219; P:cellular response to molecule of bacterial origin; IMP:MGI.
GO:0006952; P:defense response; IMP:MGI.
GO:0016064; P:immunoglobulin mediated immune response; IMP:MGI.
GO:0030889; P:negative regulation of B cell proliferation; IMP:MGI.
GO:0002924; P:negative regulation of humoral immune response mediated by circulating immunoglobulin; IMP:MGI.
GO:0002638; P:negative regulation of immunoglobulin production; IMP:MGI.
GO:0032693; P:negative regulation of interleukin-10 production; IMP:MGI.
GO:0050765; P:negative regulation of phagocytosis; IMP:MGI.
GO:0001811; P:negative regulation of type I hypersensitivity; IMP:MGI.
GO:0006911; P:phagocytosis, engulfment; IDA:MGI.
GO:0050766; P:positive regulation of phagocytosis; IDA:MGI.

IPR007110; Ig-like_dom.
IPR013783; Ig-like_fold.
IPR003599; Ig_sub.