CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039041
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Ryanodine receptor 2 
Protein Synonyms/Alias
  
Gene Name
 Ryr2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
3168IDEGAWMKRLAVFSQubiquitination[1]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Ion channel; Ion transport; Membrane; Reference proteome; Repeat; Transmembrane; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 4826 AA 
Protein Sequence
MYLCCLSTSR SSTDKLAFDV GLQEDTTGEA CWWTIHPASK QRSEGEKVRV GDDLILVSVS 60
SERYLHLSYG NSSWRVDAAF QQTLWSVAPI SSGSEAAQGY LIGGDVLRLL HGHMDECLTV 120
PSGEHGEEQR RTVHYEGGAV SVHARSLWRL ETLRVAWSGS HIRWGQPFRL RHVTTGKYLS 180
LMEDKNLLLM DKEKADVKST AFAFRSSKEK LDAGVRKEVD GMGTSEIKYG DSICYIQHVD 240
TGLWLTYQAV DVKSARMGSI QRKAIMHHEG HMDDGLNLSR SQHEESRTAR VIRSTVFLFN 300
RFIRGLDALS KRAKLPTVDL PIESVSLSLQ DLIGYFHPPD EHLEHEDKQN RLRALKNRQN 360
LFQEEGMINL VLECIDRLHV YSSAAHFADV AGREAGESWK SILNSLYELL AALIRGNRKN 420
CAQFSGSLDW LISRLERLEA SSGILEVLHC VLVESPEALN IIKEGHIKSI ISLLDKHGRN 480
HKVLDVLCSL CVCHGVAVRS NQHLICDNLL PGRDLLLQTR LVNHVSSMRP NIFLGVSEGS 540
AQYKKWYYEL MVDHTEPFVT AEATHLRVGW ASTEGYSPYP GGGEEWGGNG VGDDLFSYGF 600
DGLHLWSGCI ARTVSSPNQH LLRTDDVISC CLDLSAPSIS FRINGQPVQG MFENFNIDGL 660
FFPVVSFSAG IKVRFLLGGR HGEFKFLPPP GYAACYEAVL PKEKLKVEHS REYKQERTYT 720
RDLLGPTVSL TQAAFTPVPV DTSQIVLPPH LERIRERLAE NIHELWVMNK IELGWQYGPV 780
RDDNKRQHPC LVEFCKLPEQ ERNYNLQMSL ETLKTLLALG CHVGIADEHA EEKVKKMKLP 840
KNYQLTSGYK PAPMDLSFIK LTPSQEAMVD KLAENAHNVW ARDRIRQGWT YGIQQDVKNR 900
RNPRLVPYTL LDDRTKKSNK DSLREAVRTL LGYGYHLEAP DQDHASRAEV CSGTGERFRI 960
FRAEKTYAVK AGRWYFEFEA VTAGDMRVGW SRPGCQPDLE LGSDERAFAF DGFKAQRWHQ 1020
GNEHYGRSWQ AGDVVGCMVD MNEHTMMFTL NGEILLDDSG SELAFKDFDV GDGFIPVCSL 1080
GVAQVGRMNF GKDVSTLKYF TICGLQEGYE PFAVNTNRDI TMWLSKRLPQ FLQVPSNHEH 1140
IEVTRIDGTI DSSPCLKVTQ KSFGSQNSNT DIMFYRLSMP IECAEVFSKS VAGGIPGAGF 1200
YGPKNDLEDF DVDSDFEVLM KTAHGHLVPD RMDKDKETPK PEFNNHKDYA QEKPSRLKQR 1260
FLLRRTKPDY STSHSARLTE DVLADDRDDY EYLMQTSTYY YSVRIFPGQE PANVWVGWIT 1320
SDFHQYDTGF DLDRVRTVTV TLGDEKGKVH ESIKRSNCYM VCAGESMSPG QGRNNSNGLE 1380
IGCVVDAASG LLTFIANGKE LSTYYQVEPS TKLFPAVFAQ ATSPNVFQFE LGRIKNVMPL 1440
SAGLFKSEHK NPVPQCPPRL HVQFLSHVLW SRMPNQFLKV DVSRISERQG WLVQCLDPLQ 1500
FMSLHIPEEN RSVDILELTE QEELLQFHYH TLRLYSAVCA LGNHRVAHAL CSHVDEPQLL 1560
YAIENKYMPG LLRAGYYDLL IDIHLSSYAT ARLMMNNEFI VPMTEETKSI TLFPDENKKH 1620
GLPGIGLSTS LRPRMCFSSP SFVSISNECY QYSPEFPLDI LKAKTIQMLT EAVKEGSLHA 1680
RDPVGGTTEF LFVPLIKLFY TLLIMGIFHN EDLKHILQLI EPSVFKEAAT PEEEGGAPEK 1740
EISIDDSKLE VKEEAKAGKR PKEGLLQMKL PEPVKLQMCL LLQYLCDCQV RHRIEAIVAF 1800
SDDFVAKLQD NQRFRYNEVM QALNMSAALT ARKTKEFRSP PQEQINMLLN FKDDKSECPC 1860
PEEIRDQLLD FHEDLMTHCG IELDEDGSLD GSNDLTIRGR LLSLVEKVTY LKKKQAEKPV 1920
ASDSRKSSSL QQLISETMVR WAQESVIEDP ELVRAMFVLL HRQYDGIGGL VRALPKTYTI 1980
NGVSVEDTIN LLASLGQIRS LLSVRMGKEE EKLMIRGLGD IMNNKVFYQH PNLMRALGMH 2040
ETVMEVMVNV LGGGESKEIT FPKMVANCCR FLCYFCRISR QNQKAMFDHL SYLLENSSVG 2100
LASPAMRGST PLDVAAASVM DNNELALALR EPDLEKVVRY LAGCGLQSCQ MLVSKGYPDI 2160
GWNPVEGERY LDFLRFAVFC NGESVEENAN VVVRLLIRRP ECFGPALRGE GGNGLLAAME 2220
EAIKIAEDPS RDGPSPTSGS SKTLDAEEEE DDTIHMGNAI MTFYAALIDL LGRCAPEMHL 2280
IHAGKGEAIR IRSILRSLIP LGDLVGVISI AFQMPTIAKD GKVVEPDMSA GFCPDHKAAM 2340
VLFLDRVYGI EVQDFLLHLL EVGFLPDLRA AASLDTAALS ATDMALALNR YLCTAVLPLL 2400
TRCAPLFAGT EHHASLIDSL LHTVYRLSKG CSLTKAQRDS IEVCLLSICG QLRPSMMQHL 2460
LRRLVFDVPL LNEHAKMPLK LLTNHYERCW KYYCLPGGWS NFGAASEEEL HLSRKLFWGI 2520
FDALSQKKYE QELFKLALPC LSAVAGALPP DYMESNYVSM MEKQSSMDSE GNFNPQPVDT 2580
SNITIPEKLE YFINKYAEHS HDKWSMDKLA NGWIYGEIYS DSSKIQPLMK PYKLLSEKEK 2640
EIYRWPIKES LKTMLAWGWR IERTREGDSM ALYNRTRRIS QTSQVSIDAA HGYSPRAIDM 2700
SNVTLSRDLH AMAEMMAENY HNIWAKKKKM ELESKGGGNH PLLVPYDTLT AKEKAKDREK 2760
AQDIFKFLQI SGYAVSRGFK DLDLDTPSIE KRFAYSFLQQ LIRYVDEAHQ YILEFDGGSR 2820
SKGEHFPYEQ EIKFFAKVVL PLIDQYFKNH RLYFLSAASR PLCTGGHASN KEKEMVTSLF 2880
CKLGVLVRHR ISLFGNDATS IVNCLHILGQ TLDARTVMKT GLDSVKSALR AFLDNAAEDL 2940
EKTMENLKQG QFTHTRSQPK GVTQIINYTT VALLPMLSSL FEHIGQHQFG EDLILEDVQV 3000
SCYRILTSLY ALGTSKIYVE RQRSALGECL AAFAGAFPIA FLETHLDKHN VYSIYNTRSS 3060
RERAALSLPA NVEDVCPNIP SLEKLMTEII ELAESGIRYT QMPHMMEVVL PMLCSYMSRW 3120
WEHGPENHPE RAEMCCTALN SEHMNTLLGN ILKIIYNNLG IDEGAWMKRL AVFSQPIINK 3180
VKPQLLKTHF LPLMEKLKKK AAMVVSEEDH LKAEARGDMS EAELLILDEF TTLARDLYAF 3240
YPLLIRFVDY NRAKWLKEPN PEAEELFRMV AEVFIYWSKS HNFKREEQNF VVQNEINNMS 3300
FLITDTKSKM SKAAISDQER KKMKRKGDRY SMQTSLIVAA LKRLLPIGLN ICAPGDQELI 3360
ALAKNRFSLK DTEEEVRDVI RSNIHLQGKL EDPAIRWQMA LYKDLPNRAE DTSDPERTVE 3420
RVLDIANVLF HLEQVEHPQR SKKAVWHKLL SKQRKRAVVA CFRMAPLYNL PRHRAVNLFL 3480
QGYEKSWIET EEHYFEDKLI EDLAKPGSEL PEEDEAMKRV DPLHQLILLF SRTALTEKCK 3540
LEEDFLYMAY ADIMAKSCHD EEDDDGEEEV KSFEEKEMEK QKLLYQQARL HDRGAAEMVL 3600
QTFSASKGET GPMVAATLKL GIAILNGGNS TVQQKMLDYL KEKKDVGFFQ SLAGLMQSCS 3660
VLDLNAFERQ NKAEGLGMVT EEGSGEKVLQ DDEFTCDLFR FLQLLCEGHN SDFQNYLRTQ 3720
TGNNTTVNII ISTVDYLLRV QESISDFYWY YSGKDIIDEQ GQRNFSKAIQ VAKQVFNTLT 3780
EYIQGPCTGN QQSLAHSRLW DAVVGFLHVF AHMQMKLSQD SSQIELLKEL MDLQKDMVVM 3840
LLSMLEGNVV NGTIGKQMVD MLVESSNNVE MILKFFDMFL KLKDLTSSDT FKEYDPDGKG 3900
VISKRDFHKA MESHKHYTQS ETEFLLSCAE TDENETLDYE EFVKRFHEPA KDIGFNVAVL 3960
LTNLSEHMPN DTRLQTFLEL AESVLNYFQP FLGRIEIMGS AKRIERVYFE ISESSRTQWE 4020
KPQVKESKRQ FIFDVVNEGG EKEKMELFVN FCEDTIFEMQ LAAQISESDL NERSANKEES 4080
EKERPEEQAP RMGFFSLLTV QSALFALRYN VLTLVRMLSL KSLKKQMKRM KKMTVKDMVS 4140
AFFSSYWSVF VTLLHFVASV CRGFFRIVSS LLLGGSLVEG AKKIKVAELL ANMPDPTQDE 4200
VRGDEEEGER KPLESALPSE DLTDLKELTE ESDLLSDIFG LDLKREGGQY KLIPHNPNAG 4260
LSDLMTNPIP VPEVQEKFQE QKVKEEKEGK EETKSEPEKA EGEDGEKEEK AKDDKGKQKL 4320
RQLHTHRYGE PEVPESAFWK KIIAYQQKLL NYFARNFYNM RMLALFVAFA INFILLFYKV 4380
STSSVVEGKE LPTRTSSDAA KVTTSLDSSP HRIIAVHYVL EESSGYMEPT LRILAILHTI 4440
ISFFCIIGYY CLKVPLVIFK REKEVARKLE FDGLYITEQP SEDDIKGQWD RLVINTQSFP 4500
NNYWDKFVKR KVMDKYGEFY GRDRISELLG MDKAALDFSD AREKKKPKKD SSLSAVLVQV 4560
DLVFQVWLLL STFKDSSFLY LAWYMTMSVL GHYNNFFFAA HLLDIAMGFK TLRTILSSVT 4620
HNGKQLVLTV GLLAVVVYLY TVVAFNFFRK FYNKSEDGDT PDMKCDDMLT CYMFHMYVGV 4680
RAGGGIGDEI EDPAGDEYEI YRIIFDITFF FFVIVILLAI IQGLIIDAFG ELRDQQEQVK 4740
EDMETKCFIC GIGNDYFDTV PHGFETHTLQ EHNLANYLFF LMYLINKDET EHTGQESYVW 4800
KMYQERCWEF FPAGDCFRKQ YEDQLN 4826 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
 GO:0006874; P:cellular calcium ion homeostasis; IEA:InterPro. 
Interpro
 IPR001870; B30.2/SPRY.
 IPR000699; Ca-rel_channel.
 IPR008985; ConA-like_lec_gl_sf.
 IPR011992; EF-hand-like_dom.
 IPR002048; EF_hand_dom.
 IPR014821; Ins145_P3_rcpt.
 IPR005821; Ion_trans_dom.
 IPR016093; MIR_motif.
 IPR013662; RIH_assoc-dom.
 IPR013333; Ryan_recept.
 IPR003032; Ryanodine_rcpt.
 IPR015925; Ryanodine_recept-rel.
 IPR009460; Ryanrecept_TM4-6.
 IPR018355; SPla/RYanodine_receptor_subgr.
 IPR003877; SPRY_rcpt. 
Pfam
 PF08709; Ins145_P3_rec
 PF00520; Ion_trans
 PF02815; MIR
 PF08454; RIH_assoc
 PF06459; RR_TM4-6
 PF01365; RYDR_ITPR
 PF02026; RyR
 PF00622; SPRY 
SMART
 SM00054; EFh
 SM00472; MIR
 SM00449; SPRY 
PROSITE
 PS50188; B302_SPRY
 PS50222; EF_HAND_2
 PS50919; MIR 
PRINTS
 PR00795; RYANODINER.