CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024123
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Cadherin-2 
Protein Synonyms/Alias
 Neural cadherin; N-cadherin; CD325 
Gene Name
 Cdh2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
756RDKERQAKQLLIDPEubiquitination[1]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
 Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density (By similarity). 
Sequence Annotation
 DOMAIN 160 267 Cadherin 1.
 DOMAIN 268 382 Cadherin 2.
 DOMAIN 383 497 Cadherin 3.
 DOMAIN 498 603 Cadherin 4.
 DOMAIN 604 717 Cadherin 5.
 METAL 262 262 Calcium 1 (By similarity).
 METAL 262 262 Calcium 2 (By similarity).
 METAL 293 293 Calcium 3 (By similarity).
 CARBOHYD 190 190 N-linked (GlcNAc...) (Potential).
 CARBOHYD 273 273 N-linked (GlcNAc...) (Potential).
 CARBOHYD 325 325 N-linked (GlcNAc...) (Potential).
 CARBOHYD 402 402 N-linked (GlcNAc...) (Potential).
 CARBOHYD 572 572 N-linked (GlcNAc...) (Potential).
 CARBOHYD 622 622 N-linked (GlcNAc...) (Potential).
 CARBOHYD 651 651 N-linked (GlcNAc...) (Potential).
 CARBOHYD 692 692 N-linked (GlcNAc...) (Potential).  
Keyword
 Calcium; Cell adhesion; Cell membrane; Cleavage on pair of basic residues; Complete proteome; Glycoprotein; Membrane; Metal-binding; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 906 AA 
Protein Sequence
MCRIAGGPRT LLPLLAALLQ ASLEASGELA LCKTGFPEDV YSAVLPKTVH EGQPLLNVKF 60
SNCNRKRKVQ YESSEPADFK VDEDGTVYAV RSFPLSAEQA KFLIYAQDKE TQEKWQVAVN 120
LSLEPSLTEE PMKEPHEIEE IVFPRQLAKH SGALQRQKRD WVIPPINLPE NSRGPFPQEL 180
VRIRSDRDKN LSLRYSVTGP GADQPPTGIF IINPISGQLS VTKPLDRELI ARFHLRAHAV 240
DINGNQVENP IDIVINVIDM NDNRPEFLHQ VWNGSVPEGS KPGTYVMTVT AIDADDPNAL 300
NGMLRYRILS QAPSTPSPNM FTINNETGDI ITVAAGLDRE KVQQYTLIIQ ATDMEGNPTY 360
GLSNTATAVI TVTDVNDNPP EFTAMTFYGE VPENRVDVIV ANLTVTDKDQ PHTPAWNAAY 420
RISGGDPTGR FAILTDPNSN DGLVTVVKPI DFETNRMFVL TVAAENQVPL AKGIQHPPQS 480
TATVSVTVID VNENPYFAPN PKIIRQEEGL HAGTMLTTLT AQDPDRYMQQ NIRYTKLSDP 540
ANWLKIDPVN GQITTIAVLD RESPNVKNNI YNATFLASDN GIPPMSGTGT LQIYLLDIND 600
NAPQVLPQEA ETCETPEPNS INITALDYDI DPNAGPFAFD LPLSPATIKR NWTITRLNGD 660
FAQLNLKIKF LEAGIYEVPI VITDSGNPPK SNISILRVKV CQCDSNGDCT DVDRIVGAGL 720
GTGTIIAILL CIIILLILVL MFVVWMKRRD KERQAKQLLI DPEDDVRDNI LKYDEEGGGE 780
EDQDYDLSQL QQPDTVEPDA IKPVGIRRLD ERPIHAEPQY PVRSAAPHPG DIGDFINEGL 840
KAADNDPTAP PYDSLLVFDY EGSGSTAGSL SSLNSSSSGG DQDYDYLNDW GPRFKKLADM 900
YGGGDD 906 
Gene Ontology
 GO:0005916; C:fascia adherens; IDA:RGD.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0043234; C:protein complex; IDA:RGD.
 GO:0045202; C:synapse; IDA:BHF-UCL.
 GO:0030315; C:T-tubule; IDA:BHF-UCL.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0016339; P:calcium-dependent cell-cell adhesion; IMP:RGD.
 GO:0007156; P:homophilic cell adhesion; IEA:InterPro.
 GO:0051291; P:protein heterooligomerization; IPI:RGD.
 GO:0050770; P:regulation of axonogenesis; IMP:RGD.
 GO:0031641; P:regulation of myelination; IMP:RGD.
 GO:0032880; P:regulation of protein localization; IMP:RGD.
 GO:0035023; P:regulation of Rho protein signal transduction; IMP:RGD.
 GO:0007416; P:synapse assembly; IMP:RGD. 
Interpro
 IPR002126; Cadherin.
 IPR015919; Cadherin-like.
 IPR009124; Cadherin/Desmocollin.
 IPR020894; Cadherin_CS.
 IPR000233; Cadherin_cytoplasmic-dom.
 IPR014868; Cadherin_pro_dom.
 IPR027397; Catenin_binding_dom. 
Pfam
 PF00028; Cadherin
 PF01049; Cadherin_C
 PF08758; Cadherin_pro 
SMART
 SM00112; CA
 SM01055; Cadherin_pro 
PROSITE
 PS00232; CADHERIN_1
 PS50268; CADHERIN_2 
PRINTS
 PR00205; CADHERIN.
 PR01820; DESMOCOLLIN.