UniProt Accession

 GATA1_HUMAN; P15976; Q96GB8 

Genbank Protein ID

 X17254; M30601; AF196971; BC009797 

Genbank Nucleotide ID

 CAA35120.1; AAA35885.1; AAH09797.1 

Protein Name

 Erythroid transcription factor 

Protein Synonyms/Alias

 Eryf1; GATA-binding factor 1; GATA-1; GF-1; NF-E1 DNA-binding protein 

Gene Name

 GATA1 

Gene Synonyms/Alias

 ERYF1; GF1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
137	TSFLETLKTERLSPD	sumoylation	[1, 2]
245	NRPLIRPKKRLIVSK	acetylation	[3]

Reference

 [1] Modification of the erythroid transcription factor GATA-1 by SUMO-1.
 Collavin L, Gostissa M, Avolio F, Secco P, Ronchi A, Santoro C, Del Sal G.
 Proc Natl Acad Sci U S A. 2004 Jun 15;101(24):8870-5. [PMID: 15173587]
 [2] Controlling hematopoiesis through sumoylation-dependent regulation of a GATA factor.
 Lee HY, Johnson KD, Fujiwara T, Boyer ME, Kim SI, Bresnick EH.
 Mol Cell. 2009 Dec 25;36(6):984-95. [PMID: 20064464]
 [3] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 

Functional Description

 Transcriptional activator which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence [AT]GATA[AG] within regulatory regions of globin genes and of other genes expressed in erythroid cells. 

Sequence Annotation

 ZN_FING 204 228 GATA-type 1.
 ZN_FING 258 282 GATA-type 2.
 REGION 203 222 Required for interaction with ZFPM1.
 MOD_RES 26 26 Phosphoserine (By similarity).
 MOD_RES 72 72 Phosphoserine (By similarity).
 MOD_RES 142 142 Phosphoserine.
 MOD_RES 178 178 Phosphoserine (By similarity).
 MOD_RES 187 187 Phosphoserine (By similarity).
 MOD_RES 233 233 N6-acetyllysine; by EP300 (Probable).
 MOD_RES 245 245 N6-acetyllysine; by EP300 (Probable).
 MOD_RES 246 246 N6-acetyllysine; by CREBBP; alternate (By
 MOD_RES 246 246 N6-acetyllysine; by EP300; alternate
 MOD_RES 252 252 N6-acetyllysine; by CREBBP (By
 MOD_RES 308 308 N6-acetyllysine (By similarity).
 MOD_RES 310 310 Phosphoserine (By similarity).
 MOD_RES 312 312 N6-acetyllysine; by CREBBP (By
 MOD_RES 314 314 N6-acetyllysine (By similarity).
 MOD_RES 315 315 N6-acetyllysine (By similarity).
 CROSSLNK 137 137 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 Acetylation; Activator; Alternative initiation; Alternative splicing; Complete proteome; Direct protein sequencing; Disease mutation; DNA-binding; Isopeptide bond; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Repeat; Transcription; Transcription regulation; Ubl conjugation; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 413 AA 

Protein Sequence

Gene Ontology

 GO:0031965; C:nuclear membrane; IDA:HPA.
 GO:0005730; C:nucleolus; IDA:HPA.
 GO:0005667; C:transcription factor complex; IDA:BHF-UCL.
 GO:0017053; C:transcriptional repressor complex; IDA:BHF-UCL.
 GO:0003682; F:chromatin binding; IEA:Compara.
 GO:0008301; F:DNA binding, bending; IEA:Compara.
 GO:0001158; F:enhancer sequence-specific DNA binding; IEA:Compara.
 GO:0000978; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding; IEA:Compara.
 GO:0001078; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription; IDA:BHF-UCL.
 GO:0001077; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; IEA:Compara.
 GO:0000977; F:RNA polymerase II regulatory region sequence-specific DNA binding; IDA:BHF-UCL.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0030221; P:basophil differentiation; IEP:BHF-UCL.
 GO:0007267; P:cell-cell signaling; IEA:Compara.
 GO:0097067; P:cellular response to thyroid hormone stimulus; IDA:UniProtKB.
 GO:0097028; P:dendritic cell differentiation; IEA:Compara.
 GO:0035162; P:embryonic hemopoiesis; IEA:Compara.
 GO:0035854; P:eosinophil fate commitment; IDA:BHF-UCL.
 GO:0048821; P:erythrocyte development; IMP:BHF-UCL.
 GO:0001701; P:in utero embryonic development; IEA:Compara.
 GO:0008584; P:male gonad development; IMP:BHF-UCL.
 GO:0030219; P:megakaryocyte differentiation; IMP:BHF-UCL.
 GO:0043066; P:negative regulation of apoptotic process; IMP:UniProtKB.
 GO:0030502; P:negative regulation of bone mineralization; IEA:Compara.
 GO:0008285; P:negative regulation of cell proliferation; IEA:Compara.
 GO:2000678; P:negative regulation of transcription regulatory region DNA binding; IDA:BHF-UCL.
 GO:0070527; P:platelet aggregation; IMP:BHF-UCL.
 GO:0030220; P:platelet formation; IMP:BHF-UCL.
 GO:0045648; P:positive regulation of erythrocyte differentiation; IMP:UniProtKB.
 GO:0033690; P:positive regulation of osteoblast proliferation; IEA:Compara.
 GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IMP:BHF-UCL.
 GO:0010724; P:regulation of definitive erythrocyte differentiation; IDA:BHF-UCL.
 GO:0010559; P:regulation of glycoprotein biosynthetic process; IMP:BHF-UCL.
 GO:0071733; P:transcriptional activation by promoter-enhancer looping; ISS:BHF-UCL. 

Interpro

 IPR016374; TF_GATA-1/2/3.
 IPR000679; Znf_GATA.
 IPR013088; Znf_NHR/GATA. 

Pfam

 PF00320; GATA 

SMART

 SM00401; ZnF_GATA 

PROSITE

 PS00344; GATA_ZN_FINGER_1
 PS50114; GATA_ZN_FINGER_2 

PRINTS

 PR00619; GATAZNFINGER.