| Tag | Content |
|---|
| CPLM ID | CPLM-024047 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Neurochondrin |
Protein Synonyms/Alias | M-Sema F-associating protein of 75 kDa; Norbin |
Gene Name | Ncdn |
Gene Synonyms/Alias | Kiaa0607; Sfap75 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 61 | AALLLVTKAVKAGDI | ubiquitination | [1] | | 92 | PNRLLTTKEAPDGCP | ubiquitination | [1] | | 272 | LARILGSKLSSWQRN | ubiquitination | [1] | | 283 | WQRNPALKLAARLAH | ubiquitination | [1] | | 412 | EETSSLRKEVCQLLP | ubiquitination | [1] | | 483 | GPREILIKEGAPSLL | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Probably involved in signal transduction, in the nervous system, via increasing cell surface localization of GRM5 and positively regulating its signaling. Required for the spatial learning process. Acts as a negative regulator of Ca(2+)- calmodulin-dependent protein kinase 2 (CaMK2) phosphorylation. May play a role in modulating melanin-concentrating hormone-mediated functions via its interaction with MCHR1 that interferes with G protein-coupled signal transduction. May be involved in bone metabolism. May also be involved in neurite outgrowth. |
Sequence Annotation | MOD_RES 2 2 N-acetylserine (By similarity). |
Keyword | Acetylation; Alternative splicing; Cell projection; Complete proteome; Cytoplasm; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 729 AA |
Protein Sequence | MSCCDLAAAG QLGKAGIMAS DCEPALNQAE SRNPTLERYL GALREAKNDS EQFAALLLVT 60
KAVKAGDIDA KTRRRIFDAV GFTFPNRLLT TKEAPDGCPD HVLRALGVAL LACFCSDPEL 120
ASHPQVLNKI PILSTFLTAR GDPDDAARRS MIDDTYQCLT AVAGTPRGPR HLIAGGTVSA 180
LCQAYLGHGY GFDQALALLV GLLAAAETQC WKEAEPDLLA VLRGLSEDFQ RAEDASKFEL 240
CQLLPLFLPP TTVPPECHRD LQAGLARILG SKLSSWQRNP ALKLAARLAH ACGSDWIPVG 300
SSGSKFLALL VNLACVEVRL ALEETGTEVK EDVVTACYAL MELGIQECTR CEQSLLKEPQ 360
KVQLVSIMKE AIGAVIHYLL QVGPEKQKEP FVFASVRILG AWLAEETSSL RKEVCQLLPF 420
LVRYAKTLYE EAEEASDISQ QVANLAISPT TPGPSWPGDA LRLLLPGWCH LTVEDGPREI 480
LIKEGAPSLL CKYFLQQWEL TSPGHDTSVL PDSVEIGLQT CCHIFLNLVV TAPGLIKRDA 540
CFTSLMNTLM TSLPSLVQQQ GRLLLAANVA TLGLLMARLL STSPALQGTP ASRGFFAAAI 600
LFLSQSHVAR ATPGSDQAVL ALSPDYEGIW ADLQELWFLG MQAFTGCVPL LPWLAPAALR 660
SRWPQELLQL LGSVSPNSVK PEMVAAYQGV LVELARANRL CREAMRLQAG EETASHYRMA 720
ALEQCLSEP 729 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |