CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022464
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Opioid growth factor receptor 
Protein Synonyms/Alias
 OGFr; Protein 7-60; Zeta-type opioid receptor 
Gene Name
 OGFR 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
158LREVEVFKSSQEIQEubiquitination[1, 2]
218LRITRILKSLGELGLubiquitination[1, 2, 3, 4, 5]
283EHFRPRCKFVWGPQDubiquitination[2]
291FVWGPQDKLRRFKPSacetylation[6]
291FVWGPQDKLRRFKPSubiquitination[2, 3, 5]
296QDKLRRFKPSSLPHPubiquitination[2]
656PTRDEPAKAGEAAELubiquitination[7]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [5] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [6] Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome.
 Morselli E, Mariño G, Bennetzen MV, Eisenberg T, Megalou E, Schroeder S, Cabrera S, Bénit P, Rustin P, Criollo A, Kepp O, Galluzzi L, Shen S, Malik SA, Maiuri MC, Horio Y, López-Otín C, Andersen JS, Tavernarakis N, Madeo F, Kroemer G.
 J Cell Biol. 2011 Feb 21;192(4):615-29. [PMID: 21339330]
 [7] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661
Functional Description
 Receptor for opioid growth factor (OGF), also known as Met-enkephalin. Seems to be involved in growth regulation. 
Sequence Annotation
 REPEAT 517 536 1.
 REPEAT 537 556 2.
 REPEAT 557 576 3.
 REPEAT 577 596 4.
 REPEAT 597 616 5.
 REPEAT 617 636 6.
 REPEAT 637 656 7.
 REGION 517 656 7 X 20 AA approximate tandem repeats of
 MOTIF 267 283 Bipartite nuclear localization signal
 MOD_RES 1 1 N-acetylmethionine.
 MOD_RES 315 315 Phosphoserine.
 MOD_RES 361 361 Phosphoserine.
 MOD_RES 378 378 Phosphoserine.
 MOD_RES 420 420 Phosphoserine.
 MOD_RES 484 484 Phosphoserine.
 MOD_RES 537 537 Phosphoserine.
 MOD_RES 557 557 Phosphoserine.
 MOD_RES 617 617 Phosphoserine.  
Keyword
 Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Growth regulation; Nucleus; Phosphoprotein; Polymorphism; Receptor; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 677 AA 
Protein Sequence
MDDPDCDSTW EEDEEDAEDA EDEDCEDGEA AGARDADAGD EDEESEEPRA ARPSSFQSRM 60
TGSRNWRATR DMCRYRHNYP DLVERDCNGD TPNLSFYRNE IRFLPNGCFI EDILQNWTDN 120
YDLLEDNHSY IQWLFPLREP GVNWHAKPLT LREVEVFKSS QEIQERLVRA YELMLGFYGI 180
RLEDRGTGTV GRAQNYQKRF QNLNWRSHNN LRITRILKSL GELGLEHFQA PLVRFFLEET 240
LVRRELPGVR QSALDYFMFA VRCRHQRRQL VHFAWEHFRP RCKFVWGPQD KLRRFKPSSL 300
PHPLEGSRKV EEEGSPGDPD HEASTQGRTC GPEHSKGGGR VDEGPQPRSV EPQDAGPLER 360
SQGDEAGGHG EDRPEPLSPK ESKKRKLELS RREQPPTEPG PQSASEVEKI ALNLEGCALS 420
QGSLRTGTQE VGGQDPGEAV QPCRQPLGAR VADKVRKRRK VDEGAGDSAA VASGGAQTLA 480
LAGSPAPSGH PKAGHSENGV EEDTEGRTGP KEGTPGSPSE TPGPSPAGPA GDEPAESPSE 540
TPGPRPAGPA GDEPAESPSE TPGPRPAGPA GDEPAESPSE TPGPSPAGPT RDEPAESPSE 600
TPGPRPAGPA GDEPAESPSE TPGPRPAGPA GDEPAESPSE TPGPSPAGPT RDEPAKAGEA 660
AELQDAEVES SAKSGKP 677 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0016020; C:membrane; IEA:InterPro.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0004985; F:opioid receptor activity; NAS:UniProtKB.
 GO:0001558; P:regulation of cell growth; NAS:UniProtKB. 
Interpro
 IPR006757; OGF_rcpt.
 IPR006770; OGF_rcpt_rpt. 
Pfam
 PF04680; OGFr_III
 PF04664; OGFr_N 
SMART
  
PROSITE
  
PRINTS